Sentences with phrase «affected gene expression»

In 2005, a team of researchers at the Spanish National Cancer Research Centre led a study that analyzed DNA methylation patterns to see how they affected gene expression in identical twins ranging in age from 3 to 74.

The environmental factors also affected gene expression in the brain.

They examined whether there were differences in the composition of the breast milks» microRNAs, snippets of RNA that affect gene expression and can be passed to the infant.

Now everything we do — everything we eat or smoke — can affect our gene expression and that of future generations.

Now, new research suggests changes at the epigenetic level — specifically alterations in proteins that affect gene expression, rather than genetic mutations — could be driving childhood ependymomas.

It involves the addition of a methyl group to DNA that changes the way genes are transcribed and affects gene expression.

The answer may lie in epigenetics — the mechanism by which environmental influences affect gene expression.

The new work, published today in Cell Reports, finds that the protein ADR - 1 binds to messenger ribonucleic acid, or mRNA, and then enhances RNA editing, a process that allows a gene to be present as multiple mRNAs that can then each affect gene expression differently.

The scientists also found that the extract affects the gene expression of the bacteria, by repressing a number of genes linked with antibiotic resistance and virulence.

Their work also sheds new light on how heredity and environment can affect gene expression.

Using novel technologies developed at HMS, the team looked at how a single sensory experience affects gene expression in the brain by analyzing more than 114,000 individual cells in the mouse visual cortex before and after exposure to light.

«Experience and environmental stimuli appear to almost constantly affect gene expression and function throughout the brain.

In contrast, cis - eQTLs — which account for the majority of genetic variation that affects gene expression — regulate genes located nearby on the same chromosome.

Ishii and his team chose to focus on two histone variants named TH2A and TH2B, known to be specific to the testes where they bind tightly to DNA and affect gene expression.

A new study in fat cells has revealed a molecular mechanism that controls how lifestyle choices and the external environment affect gene expression.

It was established that the addition or removal of several small chemical groups to or from DNA could affect gene expression.

Researchers from the University of Geneva (UNIGE) and the Ecole polytechnique fédérale de Lausanne (EPFL), Switzerland, are studying the mechanisms controlling nucleosome dynamics and how this affects gene expression.

I found that negative selection against new mutations and positive selection for new mutations shape broad patterns of genomic variation and that much of the genomic variation that actually affects gene expression is under negative selection.

We notably follow the time course of structural changes in response to cues that affect gene expression either transiently or permanently: changes in genome structure during transient hormonal response of differentiated cells and stable trans - differentiation of B cells to macrophages.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

Thus, Haber muses, altered cancer metabolism is not just about energy supply, but also directly affects gene expression through regulating chromatin, and that «closes the loop» between metabolism and genetics — but still poses the chicken - or - the - egg problem of which came first.

There has been a rapidly increasing interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and thereby affect gene expression and phenotype in humans and wildlife.

However, little is currently known about how death and the length of the post-mortem cold ischemia interval specifically affect gene expression since most existing reports are based on very few genes, tissues or individuals5, 6,7,10,11,17,18.

An interesting question for the future will be the quest for the potential genetic variants that may regulate imprinting levels — iQTLs, analogously to eQTLs that affect gene expression levels.

This break surely affects gene expression rates — though its impact has not been obvious.

She has pioneered the intergration of large - scale genome and transcriptome sequencing data to understand how genetic variation affects gene expression, providing insight to cellular mechanisms underlying genetic risk for disease.

Scientists have long theorized that the way DNA is packaged affects gene expression.

The results were published this week in a special edition of Cell Reports that highlights epigenetics, a field of study focused on a layer of biochemistry that affects gene expression and that is closely coupled to DNA but does not alter the genetic code.

Next, the scientists created cardiac cells missing the same transcription factors to investigate how their interactions affect gene expression.

«We're trying to understand how the reorganization of chromatin affects gene expression,» Larabell said.

The field of epigenetics investigates how environment, nutrition and social conditions affect gene expression.

Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression.

Robert Darnell uses high throughput sequencing and other techniques to investigate the proteins that regulate RNA and thereby affect gene expression.

Based on the study, babies who get less physical contact and are more distressed at a young age, end up with changes in molecular processes that affect gene expression.

In particular, the lab investigates how alterations in epigenetics — or the heritable changes that affects gene expression without alterations in the underlying DNA sequence — contribute to epithelial ovarian cancer.

The company, intrigued with the results, wanted to know if chromium was affecting gene expression in fat metabolism.

For instance, a researcher interested in cardiovascular disease could access GTEx data to view all the genetic variants in the human genome that affect gene expression in the heart.

DNA methylation could play an important role in mediating the effects of DR because it is sensitive to the effects of nutrition and can affect gene expression memory over time.

June 4, 2015 New tool brings standards to epigenetic studies One of the most widely used tools in epigenetics research — the study of how DNA packaging affects gene expression — is chromatin immunoprecipitation (ChIP), a technique that allows researchers to examine interactions between specific proteins and genomic regions.

We have much more ability to affect our gene expression than the mainstream media and the medical community would have us believe.

And the soy peptide lunasin is the first dietary ingredient identified to affect gene expression and promote optimal health at the epigenetic level.

His research showed that comprehensive lifestyle changes affect gene expression, «turning on» disease - preventing genes and «turning off» genes that promote cancer and heart disease, as well as the first controlled study showing that these lifestyle changes may begin to reverse aging by lengthening telomeres, the ends of our chromosomes which control aging (in collaboration with Dr. Elizabeth Blackburn, awarded the Nobel Prize in Medicine).

So, you're literally affecting gene expression.

Dr. Tim Jackson: So, you're literally affecting gene expression.

These methyl groups are what affects your gene expression.

A PowerPoint which explores how DNA Methylation of promotors and Acetylation of histones affects gene expression.

This book packs the latest research about what we and our dogs eat affects gene expression and links this knowledge to practical things we can do to help our dogs live longer and healthier lives.

Maternal behaviours alter the methylation of DNA in the offspring, thereby affecting gene expression in future generations [19].

Not exact matches

Moshe Szyf, a molecular biologist at McGill University, discusses the way parental licking and grooming affects the expression of certain genes in rat pups.

Neuroscientists have over the past decade uncovered evidence, both in rodent and human studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and brain chemicals, but even more deeply, on the level of gene expression.