Or is it just for two
affected of the same breed?
Not exact matches
In the
same way that dog
breeds of different sizes have subtly different nutritional requirements, they are also
affected by different health problems.
Just as every person is different, every dog is different too and even dogs
of the
same breed can
affect an allergic person in varying degrees.
Schnelle in the 1930s first saw the disorder in the canine in Wirehaired Fox Terriers, and Moltzen - Nielsen in Germany about the
same time saw it mostly in the Wires but also in a few other
breeds Since then, puppies
of many other small, toy, and miniature
breeds between 3 and 10 months
of age have been
affected.
Only 3
of the
affected dogs had an
affected parent, and
breedings between an
affected and an unaffected parent could produce either all unaffected offspring or a mix
of affected and unaffected offspring in the
same litter.
In these
breeds, spontaneous luxation
of the lens occurs in early adulthood (most commonly 3 - 6 years
of age) and often
affects both eyes, although not necessarily at the
same time.
One mutation, which is complete deletion
of the CNGB3 gene,
affects Malamutes and Australian Shepherds, while a different single nucleotide mutation in the
same gene causes Cone Degeneration in the GSHP
breed.
In the
same way that inbreeding among human populations can increase the frequency
of normally rare genes that cause diseases, the selective
breeding that created the hundreds
of modern dog
breeds has put purebred dogs at risk for a large number
of health problems,
affecting both body and behavior.
The French Bulldog standard calls for a «well laid back» muzzle, which gives the
same affect as the well laid back «nose» in the Griffon and the English Toy Spaniel, and the «well turned up» jaw
of the Frenchie also contributes to a profile similar to the upface Toy
breeds.
Carrier dogs can have mild features
of the disease but when
bred with another carrier
of the
same Mutation, there is a risk
of having severely
affected pups.
The ideal use
of DNA tests is to prevent producing
affected puppies, while at the
same time maintaining genetic diversity and gradually decreasing the prevalence
of the disease gene (s) in the
breed.
«Since most
of these injuries happen naturally, they are more diverse,» he notes «The
affected dogs are out in the environment, they're not all the
same breed, and the injuries don't happen the
same way.
The genome
of affected dogs is compared to the genome
of healthy dogs
of the
same breed to identify defects implied in the mechanisms
of that disease.
For each disorder, healthy controls seen at the hospital during that
same time period were matched for age, weight, and sex to each
affected dog to determine risk
of disease presentation in the purebred group as compared to that
of the mixed -
breed population.
A prospective clinical study reported that 15.4 %
of French Bulldogs were
affected by corneal ulcers [8], with conformational risk factors for corneal ulcers across dog
breeds also identified in the
same study.