In the miniature schnauzer, a swallowing condition is inherited but appears to be complex with some, but fewer,
affected offspring from outcross breedings (Cox et al., 1980).
Not exact matches
Like the sugary treats fastened to the witch's cottage, the saccharine assurances
from the ER staff that this doctor was keen to help OI patients had obscured his intentions: They had brought us to a eugenicist who wished to push any of my future OI -
affected offspring into the oven.
Exposure to radiation
from cell phones during pregnancy
affects the brain development of
offspring, potentially leading to hyperactivity, one mouse study suggests.
As more and more traits are attributed to epigenesis and inheritance,
from diabetes to cancer risk to personality to homosexuality, mothers are increasingly being scrutinized for the way even their smallest decisions
affect their
offspring.
To see how the new habitats
affected these populations, evolutionary ecologist Alexander Badyaev of Auburn University in Alabama and colleague Geoffrey Hill tagged thousands of birds at each site and followed their
offspring from hatching through adulthood.
Prof. Ruiling Zhang and team
from Xinxiang Medical University explored the correlation between cyclin - dependent kinase 5 expression in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could
affect cyclin - dependent kinase 5 and its activator p35 in the hippocampus of
offspring rats.
But because the vinclozolin - induced fertility changes occurred in almost every male rat descended
from a treated mother rather than in a small percentage of
offspring (as is seen in germ line mutations caused by radiation), Skinner suspects an epigenetic mechanism — a change that doesn't mutate the DNA sequence of an animal, but rather
affects how genes are expressed.
The results
from these studies suggest that maternal antibodies targeting the brain can
affect brain development in their
offspring, resulting in altered cognition, behavior and motor skills.
They are in need of blood samples
from PRA
affected dogs, their littermates, parents and / or
offspring.
A relative risk (RR) ranging
from 1.3 to 1.8 demonstrates that
offspring of two
affected parents are more likely to be
affected than
offspring descending
from either one or two unaffected parents.
The heritability of distichiasis was estimated according to methods described for threshold characters -LRB-[14]-RRB- and found to be in the range of 0.22 - 0.51 depending on whether the estimate was based on the
offspring from matings between one
affected and one healthy parent or matings between two
affected parents.
The scale of liability (standard deviation
from threshold) within the population of dogs comprising
offspring from unaffected parents, and
offspring from one and two
affected parents, respectively, were used for the estimation of heritability according to published methods described for threshold characters [14].
The scale of liability (standard deviation
from threshold) within the population of dogs comprising
offspring from unaffected parents and
offspring from one and two
affected parents respectively were used for the estimation of heritability according to methods described for threshold characters [12].
The heritability (h2) of distichiasis was estimated at 0.22 when using
offspring from one
affected parent and 0.51 when using
offspring from two
affected parents.
In
offspring produced by two
affected dogs the relative risk was 1.4 times higher compared to
offspring from the previously mentioned mating combination and 1.8 times higher compared to
offspring produced by two unaffected dogs.
Havanese which repeatedly produce
affected offspring should be removed
from the breeding program, and their
offspring should not be used for breeding.
Test breeding of epileptic dams and sires done by veterinary researchers have produced incidences of epilepsy in the
offspring ranging
from between 38 % (
affected to nonaffected) to 100 % (breeding together of two
affected dogs).
Professor Bedford's advise at that time was: In general to contain the problem, would be DO NOT BREED
from the
affected dog, its parents, its siblings or its
offspring.
Healthy dogs which produce multiple
affected offspring, particularly with different mates, should be withdrawn
from breeding.
Several
offspring from each of those litters were severely
affected with health issues, mostly heart problems.
Dominant traits pass
from an
affected parent to its
offspring: Half of them will inherit the mutation if it has only one copy and all of them if it has two.
If they should produce cataract -
affected offspring, they should be pulled
from breeding.
The removal of
affected dogs
from the breeding pool has long been and remains an important form of prevention; the
affected dog necessarily has genes for whatever disease it has and will pass them to its
offspring.
Valuable dogs carrying unwanted genes which formerly might have been removed
from breeding programs could be bred because breeders could determine the genotypes of prospective mates and eliminate the possibility of producing
affected offspring.
There is little chance of eliminating all carriers
from a breeding program since they are not apparent «until
affected offspring are produced.
Parents, full or half siblings, and
offspring of an
affected dog should also be bred to mates
from families free of moderate to severe allergies.
Retire
from breeding any sire or dam who is
affected with or has produced
offspring with a known hereditary health defect unless said dog is used for the express purpose of testbreeding.
It should be noted that a unilaterally deaf dog can be as great a genetic risk for transmission of deafness to its
offspring as is a bilaterally deaf dog, so BAER testing of puppies
from affected breeds is important.
• Not knowingly repeat a breeding of any pair of individuals who, although free
from a hereditary defects themselves, have produced multiple afflicted
offspring with hereditary defects that
affect the quality of life of their
offspring.
A significant decrease in litter size occurred if one of two
affected parents had coloboma (3.8 pups) compared with litters
from two chorioretinal dysplasia -(CRD --RRB-
affected collies (5.2 pups) or litters by two normal collies (5.0 pups), indicating an influence of the coloboma genotype on
offspring vitality.
The polar bear has been the poster child of species loss risk
from climate change, but the emergence of the extremely rare «grolar bear,» the
offspring of a grizzly and a polar bear, is new evidence of how climate
affects species.
In their theoretical model of intergenerational transmissions of depression
from mothers to
offspring, Goodman and Gotlib (2001) argue that there are four dominant mechanisms through which depressive symptoms are transferred: heritability of depression, innate dysfunctional neuroregulatory, exposure to mother's negative behaviors and
affect, and exposure to stressful environments.