Sentences with phrase «affected offspring with»

Not exact matches

Adult offspring exposed in utero had increased liver fibrosis and inflammation, with both male and female mice affected.

The study may explain, among other things, how the mother's infection with the cytomegalovirus (CMV) during pregnancy, which affects her own and her fetus's immune system, increases the risk that her offspring will develop autism or schizophrenia, sometimes years later.

Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin - dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory.

Here, we used parentage analysis with multilocus microsatellite markers to measure how varying levels of genetic introgression with non-native rainbow trout (Oncorhynchus mykiss) affect reproductive success (number of offspring per adult) of native westslope cutthroat trout (Oncorhynchus clarkii lewisi) in the wild.

Female offspring, whose mothers had diabetes, were more often affected by MetS, higher glucose levels, and body fat content, rather than female offspring of fathers with diabetes, or no parent diseased at all.

Furthermore, lower high - density lipoprotein (HDL)- cholesterol was seen in female offspring, if both parents were affected with diabetes.

Throughout literature, GDM is associated with several adverse pregnancy outcomes affecting not only mothers but also their offspring in a sex - specific way (87, 88).

«In this study, biological offspring with two previous generations affected with major depression were at highest risk for major depression,» concluded a team led by Myrna Weissman of Columbia University and the New York State Psychiatric Institute, in New York City.

We also DNA health test for DE / CC / EFS prior to breeding and can now avoid producing any offspring affected with these disorders.

The relative risk (RR) of producing affected offspring was found to increase with the number of affected parents in the breeding combination.

However, dogs with mild disease can produce severely affected offspring.

The dog has a coat with proper furnishings but can potentially produce offspring with Improper Coat if it is mated to another Carrier or to an IC affected dog.

First - step relatives of affected dogs (parents, full and half siblings, and offspring) should be bred only to mates with pedigrees as clear of lymphoma as possible and who have no affected close relatives.

It is important to never breed two dogs together that carry one or more copies of the mutation, in order to avoid producing offspring that are affected with BFJE.

In the miniature schnauzer, a swallowing condition is inherited but appears to be complex with some, but fewer, affected offspring from outcross breedings (Cox et al., 1980).

Healthy dogs which produce multiple affected offspring, particularly with different mates, should be withdrawn from breeding.

Several offspring from each of those litters were severely affected with health issues, mostly heart problems.

In the case of recessive mutations, affected dogs — those with two copies of the mutation — should not be bred if there are serious quality - of - life or financial issues because all offspring will have at least one copy of the mutation.

Roughly the same situation occurs with a dominant disease that has a post - reproductive age of onset, since as many as half of the offspring of an affected dog will become afflicted in their lifetime, but not until they have passed on the disease gene to half of their offspring.

This means that, although the condition can be ameliorated in most cases with the proper treatment, the affected dog will always remain a carrier of the disease for the rest of its life and it can transmit the condition to its offspring.

A dog or bitch that has produced offspring with an inheritable disease, or that has a sire or dam affected by an inheritable disease is considered a carrier of that condition.

Dogs without any copies of the diseased gene or carriers with one copy of the PDP1 deficiency form of the gene will be clinically normal but the carrier will pass the affected gene to approximately half the offspring.

Dogs testing in the abnormal range were generally considered affected with vWD and at risk for transmitting an abnormal vWF gene to their offspring, and in some individuals for expressing an abnormal bleeding tendency.

Retire from breeding any sire or dam who is affected with or has produced offspring with a known hereditary health defect unless said dog is used for the express purpose of testbreeding.

With an array of problems that may have a common end result of blindness, informed breeders will not breed affected animals because those with «mild disease» may still produce severely affected offsprWith an array of problems that may have a common end result of blindness, informed breeders will not breed affected animals because those with «mild disease» may still produce severely affected offsprwith «mild disease» may still produce severely affected offspring.

The parent with the dominant trait will pass the affected gene to approximately half its offspring, and the trait will be apparent in both the parent and the affected progeny.

• Not knowingly repeat a breeding of any pair of individuals who, although free from a hereditary defects themselves, have produced multiple afflicted offspring with hereditary defects that affect the quality of life of their offspring.

A significant decrease in litter size occurred if one of two affected parents had coloboma (3.8 pups) compared with litters from two chorioretinal dysplasia -(CRD --RRB- affected collies (5.2 pups) or litters by two normal collies (5.0 pups), indicating an influence of the coloboma genotype on offspring vitality.

Research also needs to adequately control for covariates that may confound the effects of PAE, such as family processes (eg, problematic parenting or family conflict) and parental characteristics, especially maternal substance use.1, 12 Researchers also need to account for genetic liabilities that are shared by parents and offspring.13, 14 A woman's genetic risk of substance use could be passed down to her children and subsequently affect their behavior.15 Research on the consequences of PAE, therefore, needs studies with large samples, with sufficient statistical power to detect small effects, using analytical methods and designs that can account for potential confounds, including factors that are not measured.

Such a result matches with our expectation that when mothers experience a high level of depressive symptoms, a lot of which is related to mothers» own emotion dysregulation, which can affect offspring's social and emotional functioning.