In all patients, BoNTA was injected into spastic muscles of
the affected upper limb (maximum total dose: 240 units).
Motor function of
the affected upper limb was evaluated mainly using FMA, WMFT, motor activity log (MAL), and the severity of spasticity was measured with modified Ashworth scale (MAS) at BoNTA injection, discharge and 4 weeks post-discharge.
Not exact matches
Worldwide, roughly 10,000
affected children nicknamed «thalidomide babies» were born with multiple defects, including the characteristic shortened
upper limbs (a condition known as phocomelia, Greek for «seal
limbs»), before the drug was discontinued in 1961 after four years on the market.
Congenital contractures involving 1 or multiple joints (ie, arthrogryposis multiplex congenita or arthrogryposis) have been reported in fetuses and infants with presumed or laboratory - confirmed congenital ZIKV infection.20, 24,36,37,41 The clinical picture of congenital contractures varies among
affected infants in regard to type (proximal or distal), laterality,
upper or lower
limb, and severity, likely reflecting variations in neurologic damage (Figure 4).
Usually, an
upper arm will be
affected first, followed by a femur or ulna, and often the problem will appear in another bone in the original
limb or its partner.