It is important to remember that to determine if a pattern of inheritance exists it is necessary to know also which animals are not
affected with seizures, especially those with close degrees of relatedness (aunts, uncles, cousins, grandparents, etc) to the hounds with seizures.
The information in this web site attempts to answer some of the questions asked by owners and breeders of Irish Wolfhounds
affected with seizures by presenting some of the statistical data collected to date.
Follow - up contact is attempted with owners who have submitted forms for animals
affected with seizures to clarify and expand information when necessary.
A strain called Charlottes web has had remarkable
affects with seizures
Not exact matches
It also added that the
seizure of the equipments by the police has
affected it's business operations due to the nature of its contractual agreement
with E&P.
The next step will be to test it
with live cells and the researchers hope eventually to, for example alleviate pain, stop epileptic
seizures, and reduce the symptoms of Parkinsons disease, using exactly the required dose at exactly the
affected cells.
As this rare genetic neurological disease develops,
affected girls experience slowed growth, a loss of communication skills and use of the hands, problems
with movement and coordination, difficulty breathing, and
seizures.
One of 100,000 children is born
with Menkes disease, a genetic disorder that
affects the body's ability to properly absorb copper from food and leads to neurodegeneration,
seizures, impaired movement, stunted growth and, often, death before age 3.
People
with tonic clonic
seizures (formerly known as grand mal
seizures) that
affect the entire brain are more likely to die suddenly than people
with partial
seizures that
affect an area of the brain.
Patients
with Alzheimer's disease, Fragile X syndrome, Down syndrome, and autism are particularly susceptible to
seizures, 12 and the focus of much research at the Waisman Center of Developmental Disabilities has been on the myriad ways drugs, diet and genetic manipulation can
affect amyloid beta levels,
seizure threshold and behavioral phenotypes.13 In an editorial entitled «Concocting the Right Diet for Brain Health» published December 2011 in Translational Medicine, Dr. Westmark expressed concern about the risks of soy: «The prevailing view is soy is healthy, but much remains to be learned regarding its effects on brain development and function.»
Any dog breed can be
affected,
with the larger breeds having more severe
seizures.
Epilepsy (
seizures) is a major concern in Golden Retrievers,
with an estimated 7 % of the breed
affected.
Phenobarbital was by far the most commonly used drug for amelioration of the
seizures,
with 30.8 % of all
affected dogs receiving this drug.
The age at first
seizure ranged from 6 months to almost nine years of age in the
affected Irish wolfhounds,
with the majority (73.8 %) of first
seizures occurring at or before three years of age.
Also, types of
seizures were variable within the litters
with multiple
affected dogs.
All but four of the
affected animals in this study experienced recurring grand mal
seizures,
with seizure duration varying from 30 seconds to 4 minutes.
The high incidence of
seizures in the Irish wolfhound along
with the decreased longevity in
affected animals and unsatisfactory treatment modalities underscore the need for a breeding program designed to eliminate the disease from the breed.
Of the 126
affected dogs that have died, 76 deaths (60.3 %) were directly attributed to the
seizure disorder,
with the cause of death reported as death during
seizure (16.1 % of all
seizure related deaths) or euthanasia because of uncontrolled
seizures (65.8 %), hepatotoxicity from phenobarbital treatment (6.6 %), aspiration during
seizures leading to fatal pneumonia (6.6 %), or euthanasia because of non-recovery after a
seizure (3.9 %).
However, when only those dogs
with onset of
seizure activity before 3 years of age were taken into account, there was not a significant difference between the percentage of
affected females and males.
The prodromal signs observed by owners or breeders in
affected dogs included: teeth chattering, anxiety, mental detachment -LRB-» spaciness»), standing
with a blank stare, wandering aimlessly, increased attention seeking, and sitting or lying down immediately before a
seizure.
Six of the
affected dogs began
with mild generalized
seizures that progressed to grand mal
seizures over the course of their disease.
As there is currently no DNA testing available for Beagle Epilepsy and no way to determine if a Beagle is
affected with or carries the gene (s) for Epilepsy, the best we can do as breeders is to be completely honest when we produce a Beagle who has
seizures.
While some breeds appear to have a genetic predisposition to epilepsy2, any dog may be
affected,
with many experiencing their first
seizure between 1 and 3 years of age.3
Furthermore, recent vaccination of genetically susceptible breeds has been associated
with transient
seizures in puppies and adult dogs, as well as a variety of autoimmune diseases including those
affecting the blood, endocrine organs, joints, skin and mucosa, central nervous system, eyes, muscles, liver, kidneys, and bowel.
Cats
with advanced secondary hypertension will typically exhibit problems associated
with the systems that are
affected by the condition: the ocular system (sudden blindness or retinal hemorrhaging); the renal system (poor appetite, weight loss, increased drinking and urination); the neurologic system (
seizures, disorientation); and the cardiovascular system (difficulty in breathing).
The study aimed to recruit both dogs
affected by IE, and controls
with no history of recurrent
seizure activity.
Canadian information physically located on US soil which would be required to be kept confidential under Canadian laws (PIPEDA) is exposed to compulsory disclosure to, or
seizure by, US government officials on demand,
with no opportunity for our government or the
affected Canadian organization or individual to have any notice or input into such disclosure.
However, the distinct procedural acts
with which the investigation is conducted and advanced, for example a disclosure or search and
seizure order, or a decision on the access to the investigation file, can be challenged
with the competent court by any person
affected by such act or procedural decision.