Sentences with phrase «affecting nucleosome»
«Our paper shows that suppressing ASF1 induces ALT by affecting nucleosome assembly,» he says.
https://www.sciencedaily.com/ Not exact matches
Put simply, nucleosomes and methylation can affect transcription leading to changes in cells.
«It is important to understand how nucleosomes are moved, ejected or restructured, as this will affect the accessibility of promoter DNA, which in turn influences the expression of the corresponding genes,» explains David Shore, professor at the Department of Molecular Biology of the Faculty of Science at UNIGE.
Researchers from the University of Geneva (UNIGE) and the Ecole polytechnique fédérale de Lausanne (EPFL), Switzerland, are studying the mechanisms controlling nucleosome dynamics and how this affects gene expression.
Gene ontology analysis of the genes affected across several tissues (Supplementary Fig. 8) shows enrichment for genes in the extracellular region and genes involved in nucleosome and chromatin assembly and in protein — DNA complexes.