Sentences with phrase «affecting telomere»

How much a certain change — say, running or cutting back on fat — is going to affect your telomeres, if at all, is a level of specificity that the research can't yet provide.

Two of those genes, TERT and TERC, like PARN and RTEL1, affect telomere length.

But few studies have addressed whether or not events early in a person's life might affect telomere length.

We reciprocally cross-fostered urban and rural nestling great tits (Parus major L.) to study how growing up in an urban versus rural habitat affected telomere length (TL)-- a suggested biomarker of longevity.

The Telomere Effect includes information on how sleep, exercise, diet and even our social connections profoundly affect our telomeres and how chronic stress can eat away at them.

In their study, the researchers first confirmed that a gene previously associated with telomere length also affected telomeres in a subset of their UK sample of more than 2,700 people.

The new study was designed to determine if the lifestyle changes would affect telomere length and telomerase activity in these men over a longer time period.

Not exact matches

The parts affected are the telomeres — stretches of DNA that cap the ends of chromosomes.

Telomeres are essential parts of human cells that affect how our cells age.

The team found that telomere length was especially affected in larger males, compared with females or smaller males.

It is unclear how the entire body is affected because Spector looked only at telomeres, nucleotides on the ends of chromosomes that slowly erode as cells copy themselves during normal aging.

An essential part of human cells they affect how our cells age — as people with longer telomeres live longer lives.

Human diseases that include dyskeratosis congenita, aplastic anemia, and idiopathic pulmonary fibrosis have been genetically linked to mutations that negatively affect telomerase activity and / or accelerate the loss of telomere length.

The gradual shrinking of telomeres negatively affects the replicative capacity of human adult stem cells, the cells that restore damaged tissues and / or replenish aging organs in our bodies.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

The telomeres are located at the ends of the chromosomes, and affect the lifespan and health of an individual.

Researchers at Carnegie Mellon University have found an association between lower socioeconomic status during childhood and adolescence and the length of telomeres, protective cap - like protein complexes at the end of chromosomes that ultimately affect the susceptibility to colds in middle - aged adults.

However, we still know very little about how an animal's environment per se affects TL and telomere attrition [11].

The team found that deleting the PIN domain from Chp1 prevented heterochromatin formation at the telomeres but didn't affect formation at the centromere.

Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with higher inflammation, shorter telomeres, and lower activity levels of telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13

«Our findings reveal a critical role for telomere length in a mouse model of age - dependent human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent disease and also a system to test novel therapeutics for aortic valve disease.»

The scientists think that telomere length affects disease severity by changing gene expression in pathways implicated in CAVD, such as anti-inflammatory and anti-calcifications pathways.

Erosion of telomeres has long been associated with diseases of aging, but how telomere length affects human disease has remained largely a mystery.

Telomeres work to keep chromosome ends from deteriorating or fusing with a neighboring chromosome, affecting how quickly cells age and die.

The research published by GenoMEL has identified inherited genes which increase melanoma risk which are pigment genes (affecting skin colour and vulnerability to sunburn), genes which are associated with having more moles (melanocytic naevi) and others associated with a part of the genetic makeup of the cell called the telomere.

It's possible to measure the length of telomeres and assess whether therapies affect the normal aging process.

This cellular damage affects proteins and DNA replication, and inhibits repair through many complex processes, including telomere shortening in the DNA components.30 - 31

In this podcast I discuss some of the mechanisms by which chronic stress (and rumination) affect the brain and brain aging, the gut and inflammation, the immune system, and biological aging through acceleration of telomere shortening.

His research showed that comprehensive lifestyle changes affect gene expression, «turning on» disease - preventing genes and «turning off» genes that promote cancer and heart disease, as well as the first controlled study showing that these lifestyle changes may begin to reverse aging by lengthening telomeres, the ends of our chromosomes which control aging (in collaboration with Dr. Elizabeth Blackburn, awarded the Nobel Prize in Medicine).

[6] Telomere Length and Long - Term Endurance Exercise: Does Exercise Training Affect Biological Age?

This is important, since the rate of change of your telomere length is very individual and can be affected, both positively and negatively, by many contributing factors — including genetics, lifestyle, stress and environment.