Sentences with phrase «affects cell development»

Petroleum / Petrolatum / Paraffin / Mineral Oil — Found in various products from lipsticks to moisturizers this is a petrochemical that affects cell development and results in premature aging.

Not exact matches

Exposure to radiation from cell phones during pregnancy affects the brain development of offspring, potentially leading to hyperactivity, one mouse study suggests.

Stem cells play an important role in the development of many organs, and the loss of these cells at birth could affect babies» later development, the researchers write.

A growing body of research indicates that the B2M - MHC I complex, which is present in all cells in the body except red blood cells and plasma cells, can act in the brain in ways not obviously related to immunity — guiding brain development, shaping nerve cell communication, and even affecting behavior.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

Hormones regulate a lifelong reshaping of our neuronal pathways, programming a turnover and pruning of brain cells — a process that begins in the womb and continues to affect our intellectual, emotional and social development in adulthood.

They generated an experimental model to investigate how one of the genes commonly mutated in blood cells of elderly humans, TET2, affects plaque development.

«In the case of Alzheimer's disease, one of the first cell types affected by the pathology is one that we've observed to play a leading role in the development of the entorhinal - hippocampal network.»

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

This allows us to reveal how drugs affect heart functions in a scenario where the two cell populations are closely coupled,» said Ben Maoz, Ph.D., a co-first author on the second study, who also is a Technology Development Fellow at the Wyss Institute and a member of Parker's group.

Among these is a substance, called EZH2, that affects the expression of a wide variety of genes, including those involved in cell development and differentiation.

DNA sequences were once thought to be identical from cell to cell, but it's increasingly understood that mutations can arise during brain development that affect only certain groups of brain cells.

The work, published online this week in the journal Nature, suggests modulation of «enhancer - directed RNAs» or «eRNAs» could provide a new way to alter gene expression in living cells, perhaps affecting the development or pathology of many diseases.

Molecular analysis showed that heart cells in affected animals were poorly developed and had mitochondrial defects, indicating that Sap130 - Pcdha9 gene interactions play a crucial role not only in heart development but also in regulating metabolic function of the cardiac muscle.

The team also found that the flightless cormorants have an abnormally high number of genetic mutations affecting cilia — small, hair - like structures that protrude from cells and regulate everything from normal development to reproduction.

This finding suggests that in human babies, factors that shape the microbiome — natural ones such as breastfeeding, or therapeutic, such as antibiotics — may affect the immune cells in the baby's brain and consequently the brain's development.

Again, the appearance of a protein in a certain part of the egg cell may affect embryonic development or the formation of organs days and weeks later.

Therefore, identification of molecules that affect both parasites during their release from infected host cells not only highlights robustness of the complementary screening approach we adopted, but also conserved drug targets for pan anti-parasitic drug development,» Dr Dhanasekaran Shanmugam from NCL added.

Forcing the cells to organize and stretch into three - dimensional tissue helps spur development and coaxes them into resembling more mature cells that can better predict how a drug will affect adult heart cells.

It is the first time that evidence has been found to suggest that local anaesthetic could affect tooth cell growth and potentially impact upon tooth development.

Scientists are beginning to understand that genetic mutations are not the sole contributors to disease development and that the way in which genes are arranged in our cells can affect whether they function appropriately — that is, whether they are turned on or off.

A study led by Dr. Bing Hu at Plymouth University Peninsula Schools of Medicine and Dentistry and involving other researchers from China and Switzerland, suggests for the first time that the use of local anaesthetic may affect tooth cell growth and the development of children's teeth.

A region of the gene that produces the PACAP38 protein has held nearly constant, even in humans, presumably because the protein plays diverse roles in neuron communication and is essential for normal development of the cerebellum, affecting brain cell migration, for example.

Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild - type mice

The development of GVHD was equivalent between the two groups (data not shown), suggesting that treatment with X4 - ZFNs did not affect CD4 + T cell effector functionality.

Patients with Diamond - Blackfan anemia (DBA)-- an inherited disorder which disrupts the development of red cells in affected patients, but which does not affect the development of other blood cell types — offer researchers a particularly useful model for the study of these proteins.

Based on our recent development allowing the efficient and robust conversion of human pluripotent stem cells into affected spinal motor neurons and non - affected cranial motor neurons, our objective is to deepen the mechanisms involved in the specific degeneration of spinal motor neurons in SMA as well as the mis communication of these neurons with their muscular target.

Constitutive Expressor of Pathogenesis - Related Genes5 affects cell wall biogenesis and trichome development.

We are also working to show how changes in the structure of chromosomes affect heart development, and to determine how immune cells contribute to the build - up of plaque in arteries.

To understand why skin cells in diverse parts of the body have different characteristics - how cells know their «positional identities» - a fact that guides the diagnosis and treatment of many skin diseases, Dr. Chang and his colleagues are seeking to define in molecular terms how the expression of different genes in stromal cells determines their ability to affect the development of skin cells.

Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild - type mice.

This visualization shows tightly - packed DNA in a mouse cell's nucleus at different stages of development, seen here in a semi-triangular form as a mature nerve cell; in a roundish shape as a multipotent stem cell; in a more oval form as a neuronal progenitor; and as a more fragmented structure that shows how removing a specialized binding protein (HP1β knockout) affects the structure of the DNA - packing material, called heterochromatin, in a mature neuron.

Using the Mfrprd6 model, and others with similar protein localization and phenotypes when mutated, we hope to gain a better understanding of how RPE cells affect photoreceptor development and the process of phagocytosis.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

His team later found that complete loss of PTEN paradoxically triggers senescence, an arrested state that delays or blocks cancer development in affected cells.

If not degraded and removed, glycosaminoglycans can accumulate in cells and tissues, resulting in progressive, permanent damage affecting appearance, physical abilities, organ function and often mental development in young children.

AAT is a naturally occurring anti-inflammatory protein that affects immune cells that are thought to be involved in the development of type 1 diabetes.

CREBBP (CBP) and EP300 are general transcriptional co-activators, which are involved in many biological processes like maintenance of genomic stability by affecting DNA replication and DNA repair as well as cell growth, transformation and development.

Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.

Aberrant regulation of the epigenetic information results in changes in cell fate decisions, thereby affecting development and tissue homeostasis, and ultimately leading to disease, such as cancer.

Until now, lincRNAs have been studied primarily in cell lines rather than at the organismal level, which has precluded research into how lincRNAs affect growth and development.

The work at the ESRF will help CRELUX / WuXi AppTec to support their clients in the discovery and development of novel and more specific drugs that can influence AMPK activity in the cell and, as a result, adjust the energy balance in disease affected organs.

This is the first time a lncRNA has been found to play a role in red blood cell development and the first time a lncRNA has been shown to affect programmed cell death.

By affecting the rate of cell differentiation and gene expression, thyroid hormones regulate the growth and migration of neurons, including synaptic development and myelin formation in specific brain regions.

Estrogen is a pro-growth hormone that regulates the menstrual cycle, affects the mood, promotes cell division and development especially in the female organs such as ovaries, cervix, fallopian tubes, vagina and breast tissue.

Early Childhood Expert Says Science Shows Impact of Early Experiences on Brain Development Journal Star, January 15, 2013 «Children are born with a certain number of brain cells, but the neural circuitry develops dramatically in the first years of life — and experiences affect how those connections are made, said [Professor] Jack Shonkoff, director of Harvard's Center on the Developing Child.»

In these breeds the disease results from abnormal or arrested development of the photoreceptors — the visual cells in their retina, and affects pups very early in life.

And lab experiments have shown that estrogen may inhibit tumor development in the colon by affecting cell growth, or by lowering levels of a cancer - linked hormone called IGF - 1.