Sentences with phrase «affects genes involved»

The growth of long facial feathers, creating the appearance of muffs and beards on chickens, is caused by a chromosomal rearrangement affecting a gene involved in feather development, report Xiaoxiang Hu of the China Agricultural University in Beijing and colleagues, in a new study published on June 2 in PLOS Genetics.

Not exact matches

However, Darnovsky points out that the genes involved affect development and metabolism — very much linked to personal identity.

These conditions are each caused by mutations in a particular gene, and affect different enzymes involved in breaking down galactose.

It involves the addition of a methyl group to DNA that changes the way genes are transcribed and affects gene expression.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Comparisons of the Neandertal genome to the genomes of five present - day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.

The new gene permanently switched on a set of genes normally affected by insulin and involved in the immune system.

Next, he synthesised 50,000 DNA strands with sequences that almost matched parts of the 24 genes involved in lycopene production, but with a range of variations that he hoped would affect the amount of lycopene produced.

The findings highlight specific sets of genes and the brain cells they affect as being involved in regulating anxiety.

«Rapamycin affected the expression of genes involved in calcium regulation, mitochondrial metabolism, hypertrophy and inflammation,» said Melov.

Those deletions tended to involve genes that affect cilia, cellular structures that are important for signaling and patterning in embryonic development.

Among these is a substance, called EZH2, that affects the expression of a wide variety of genes, including those involved in cell development and differentiation.

This work, conducted by Yuliang Wang, now a senior research associate at Oregon Health & Science University, uncovered intriguing differences involving genes that affect the cells» metabolism.

«The call of the sea: Mammalian evolutionary transitions back to the sea: Hundreds of genes involving smell, taste, skin, muscle and metabolism most affected.»

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

«As we find genes involved in Tourette syndrome and understand more about its biology, we move closer to our ultimate goal of developing treatments to help children affected by the disease.»

Although previous research has identified genes involved with behaviors seen in eating disorders such as anorexia or bulimia, little is known about how natural variation in these genes could affect eating behaviors in healthy people.

«It also affected the expression of certain genes in the brain that are involved in «neuroplasticity», which may be associated with memory impairment,» says Morris.

The researchers found that over 25 percent of index patients with normal results from commercial testing of BRCA1 and BRCA2, but with families severely affected by breast cancer, could be resolved by sequencing all genes known to be involved in breast cancer.

Moreover, approximately 30 % of follicular lymphoma patients lose also a portion of chromosome 6, affecting multiple genes involved in suppressing the emergence of a tumor.

«Crohn's disease is a complex disorder with multiple genes and environmental factors involved, which disproportionally affects individuals of Ashkenazi Jewish ancestry,» explained lead researcher Inga Peter, Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai in New York City.

The researchers assessed how the mothers» nutrition affected epigenetic changes (or DNA methylation) of IGF2, a gene involved in fetal development and the brain development of areas implicated in ADHD — the cerebellum and hippocampus.

The discovery of genes involved in the production of DMSP in phytoplankton, as well as bacteria, will allow scientists to better evaluate which organisms make DMSP in the marine environment and predict how the production of this influential molecule might be affected by future environmental changes, such as the warming of the oceans due to climate change.

Because cancers involving p53 are so common, Bond and his colleagues suspected that inherited mutations in the gene, or in genes it activates, could affect cancer risk.

In CF a defect in a gene for a transporter protein involved in mucus production affects many organs and tissues, but its most serious effects are often seen in the lungs.

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

Thousands of genes in fibroblasts and mouse macrophages, including those involved in inflammation, metabolism, apoptosis, growth, and differentiation are affected.

The current work shows that changes in the genetic code of a particular gene can control epigenetic marks at different genes, implying that a gene's genetic code can affect whether other genes are turned on and off, which makes it important to understand the function of all genes involved, not just the one with the so - called misspelling.

The genetic variant may affect CHD risk by reducing the expression of the GLUL gene which is involved in glutamine / glutamic acid metabolism.

Although this compound exhibits a preference for AT - rich regions, overall it is expected to affect expression of a multitude of different genes involved in diverse biological functions.

Researchers studying worms have discovered new information on a gene that is involved in the development of Joubert syndrome, a genetic disorder that affects the brain stem.

However, we still need to pinpoint which genes are involved, how they may interact to affect risk, and what are the exact molecular mechanisms behind this.

Gene ontology analysis of the genes affected across several tissues (Supplementary Fig. 8) shows enrichment for genes in the extracellular region and genes involved in nucleosome and chromatin assembly and in protein — DNA complexes.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Although most adult leukemias involving MLL affect a different part of the gene, the breakpoints found in infant leukemias and secondary leukemias occur predominantly in the small region altered by the bioflavonoids.

The genes they affect impair pathways known to be involved in the illness.

Many medical - genetic syndromes show a clear connection between genetic alteration and typical facial gestalt [49], hence genes involved in affected individuals may also contribute to normal variations in facial shape.

To truly understand and treat complex neuropsychiatric disorders, we need to know what behaviors are affected, which brain regions are involved, which genes, molecules, and cell types in these regions might be involved, and how the environment affects the propensity to develop these disorders.

By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu.

They found that compared to dengue infection, Zika infection more strongly affects expression of genes involved in DNA replication and repair, processes that are important in brain development.

Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5 % of the population, remain obscure.

Concurrently a study in Labrador retrievers has identified a mutant variant of ATP7B (Chr22) the Wilson disease copper transporter gene in their affected dogs while COMMD1 does not appear to be involved in affected dogs in this and other breeds.

The canine disease is compared to similar diseases in other species, most often humans, to determine if there are any possible candidate genes (i.e., genes that are known to be involved in these similar diseases or in the normal processes affected by the disease may offer important leads).

However, more than one gene may be involved and affected genes may vary between breeds.

In terms of CRD (canine retinal dystrophy), the standard wire - haired dachshund, miniature long - haired dachshund (MLHD), Glen of Imaal terrier and pit bull terrier are the only dog breeds thus far affected, and the genes involved have been identified in all but pit bull terriers.»

Future treatments may involve the administration of a miniature version of the affected gene, called a microgene, into the body to protect muscles, but is not yet available.

Many of the genes affected by the temperature treatment are also involved in important developmental processes (Long et al., 2012).