«It's predominant in the striatum and specifically
affects synaptic plasticity induced by dopamine signaling.
«Based on these findings, it was particularly interesting to find out if and to what extent the mGlu5 receptor
affects synaptic plasticity and, consequently, memory formation in the CA3 region,» explains Hagena.
Not exact matches
Maternal alcohol consumption prior to and during pregnancy significantly
affects cognitive functions in offspring, which may be related to changes in cyclin - dependent kinase 5 because it is associated with modulation of
synaptic plasticity and impaired learning and memory.
However, there is no consensus about the extent to which basal
synaptic transmission (BST) and
synaptic plasticity are
affected in these models.
It is likely that a combination of several factors (e.g. age - related changes at the level of gene expression, infectious agents, toxic compounds, and head trauma)
affects the neuronal milieu and initiates neuropathological processes leading to the formation of toxic tau and amyloid β species, reduction of
synaptic plasticity, and neuronal loss resulting in development of sporadic AD.»