Sentences with phrase «affects the cell linings»

Canine parvovirus (CPV) affects cells lining the digestive tract.

Not exact matches

The Times of India says that the Delhi Police Cyber Cell has confirmed the registration of the criticism and that the personal keys of Coinsecure's pockets leaked on - line plus all the information logs referring to affected wallets had been erased.

Power has not been fully restored, affecting Garcia - Arraras» own samples of monoclonal antibody cell lines collected for organ regeneration research.

The investigators found that CCL28, which is over-produced in joints affected by rheumatoid arthritis, attracts the surface - lining cells that carry its receptor.

«This model was trained on genetic data from human tumors in The Cancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» Greene said.

Today's version of the NPS1 model includes a digital simulation of every building in the area affected by the bomb, as well as every road, power line, hospital, and even cell tower.

Each of the four compounds was then tested in the lab to see how it would affect a line of prostate cancer cells relatively sensitive to the chemotherapeutic Paclitaxel, commonly used to treat prostate cancer patients.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

To see how alcohol affects resistance to infection, Gyongyi Szabo of the University of Massachusetts Medical School in Worcester and colleagues exposed monocytes — white blood cells involved in the front - line defence against infection — to chemicals that mimic viruses and bacteria.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

Putting together their analyses of the mitochondrial DNA in each tumour cell line and the metabolic pathways at work, the team were able to deduce how each cell line's genetics directly affected its ability to multiply.

Since intestinal stem cells are the only ones that can replace gut lining tissue, their aging affects the entire intestine.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

LINE - 1 variations affect 44 to 63 percent of cells in the brain, the researchers estimated.

This work, led by Dr Patrick Varga - Weisz shows how chemicals produced by bacteria in the gut from the digestion of fruit and vegetables can affect genes in the cells of the gut lining.

The team's findings may also be relevant to inflammatory disorders that affect other parts of the body, such as the linings of the gut and bowel, which, like the skin, are replenished by epithelial stem cells.

The researchers believe that MitoQ affects the endothelium, a thin layer of cells that lines our blood vessels.

TNGB collects, stores and distributes high quality biological materials (nucleic acids, cell lines and tissue samples) linked to relevant clinical and genetic data from patients affected by inherited diseases.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

The first hint that HDAC inhibitors might affect SMA came in a 2001 study showing that the weak inhibitor phenylbutyrate increased protein levels in patient cell lines and SMA mice (Proc Natl Acad Sci 2001; 98:9808 — 9813).

The next step based on these novel head and neck cancer discoveries, the scientists agree, is to tease out how the genes function in normal cells, whether they form the lining of the larynx, pharynx, or another anatomical site affected by head and neck cancer.

In the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.»

In addition to our computational work, we run a small wetlab where we use CRISPR - Cas genome editing in human cell lines to obtain a deeper understanding of how genetic variants affect the cell.

The technical evaluation of projects may require the provision of additional data such as information on the genetic modification of your mutant mouse line if applicable (e.g. affected gene, MGI ID of the gene, type of mutation, ES - cell line used, genetic background (e.g. number of backcross generations), safety level, description of DNA modification, vector, remaining non-recipient DNA, donor organism), mutant phenotype (s), special housing or care requirements, current sanitary status, and intellectual property rights (who generated the mouse line, owner of the mouse line)

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Whereas conditioned medium from ABL1 / ABL2 - depleted breast cancer cells did not affect RANKL abundance in osteoblasts compared with the cells treated with control conditioned medium (Fig. 5E), we found that conditioned medium from breast cancer cells lacking ABL kinases increased OPG abundance in the osteoblast cell line (Fig. 5F).

Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.

ACTB mRNA expression levels in lymphoblastic lines and fibroblasts derived from affected individuals were decreased in comparison to those in control cells.

Until now, lincRNAs have been studied primarily in cell lines rather than at the organismal level, which has precluded research into how lincRNAs affect growth and development.

Kucherlapati: Without thinking about modifying the human genome line, would this technology have the ability to affect the health of humans by modifying the stem cells?

The second is renal cell carcinoma, which affects the lining of the tiny tubes that filter blood.

Red foods like red bell peppers and tomatoes contain a phytochemical called lycopene, which may have an anti-inflammatory affect on the cells lining the heart and blood vessels, and may reduce the risk of developing prostate cancer among other cancers such as breast, lung, bladder, ovarian, and colon.

The bottom line is that lack of proper hydration can adversely affect cells and cellular reactions, quickly leading to a state of unhealth.

«Besides affecting tumor cells» directly, phytates «can act on [our] immune functions» by augmenting natural killer cell activity, the cells in our body that hunt down and dispose of cancer cells, as well as neutrophils, which help form our «first line of defense.»

The most likely organ to be affected is the gut, which is directly exposed to food; endothelial cells, which line blood vessel walls, and immune cells which circulate in blood, as blood is the next location after the gut exposed to food molecules entering the body; and lastly organs which interact closely with the blood, such as the thyroid.

Otitis externa means that the inflammation affects the layer of cells lining the outer or external portion of the ear canal.

Once the aerosolized organisms are inhaled, they adhere to the lining of your dog's upper airway passages to fester and affect the cells of those lining tissues, prompting your dog to cough.

Basal cell tumors Basal cells line the deepest layers of the skin and that is what is affected with basal cell tumors.

In affected dogs, the intestine is taken over by inflammatory cells, eventually leading to scar tissue throughout the lining of the digestive system.

The seizures affected both personal cell phones and office lines in AP bureaus in New York, Hartford and Washington.

Analyzed effects of different pH environment, and cell wall affecting agents on the growth of wild and mutant cell lines of Candida albicans.