«Over 40 % of prostate cancers lose PTEN and some lose both PTEN and another tumour suppressor gene, INPP4B, but we didn't previously have a clear picture of how
this affects tumour growth,» says IMED Biotech Unit scientist Sabina Cosulich, at AstraZeneca.
In order to determine how Tie2 - deficient pericytes
affected tumour growth kinetics, Luciferase - expressing B16 melanomas were grown s.c. in WT and Tie2PEKO mice and tumour growth was traced non-invasively over time (Fig. 5e).
Not exact matches
I knew that antibiotics can
affect mitochondria and I've been doing a lot of work recently on how important they are to the
growth of
tumours, but this conversation helped me to make a direct link.»
Samples of
tumours from bowel cancer patients given different doses of resveratrol showed that even lower doses can get into cancer cells and potentially
affect processes involved in
tumour growth.
Genetic inactivation of Tie2 in pericytes leads to strongly enhanced
tumour growth, demonstrating that Tie2 in pericytes
affects the plasticity window of the
tumour - associated vasculature.
We next asked if the rather mild postnatal phenotype in Tie2PEKO mice
affected the vascularization of
tumours and possibly
tumour growth.
Conclusions «In conclusion, creatine supplementation was able to mitigate
tumour growth in rats -LSB-...], without
affecting survival rate», the researchers summarize.