Sentences with phrase «affinity maturation of»
This difference in binding ability to the two immunogens suggests the R2 immunogen may have driven the earlier stages of affinity maturation of this lineage in llama 1, which resulted in clones that could also recognize 96ZM651.02 gp140 as the immune response progressed and the lineage developed breadth via mutations in the V gene region.
http://journals.plos.org/ Not exact matches
«Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association» was recently published in the scientific journal Nature Communications.
After affinity maturation, two of the designed proteins, HB36 and HB80, bind H1 and H5 HAs with low nanomolar affinity.
In this context, the Lingwood laboratory studies B cell antibody responses to both HIV and influenza with the goal of 1) understanding how antigenic sites of vulnerability are initially perceived by specific germline B cell receptor (BCR) sequences and 2) how that recognition process can direct antibody affinity maturation toward production of broadly neutralizing anti-viral responses.
Understanding such antibody affinity maturation is a key part of vaccine development.
Iterative cycles of hypermutation and selection continue until antibodies of high antigen binding specificity emerge (affinity maturation).