Sentences with phrase «after several members of the family»

Not exact matches

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The rumours on social media became the subject of several discussions in the country and beyond after the Member of Parliament (MP) for New Juaben North, Mark Assibey - Yeboah urged persons duped in the scam to blame it on the first family.

They are members of the Al - Sayyid Bedouin tribe, founded 200 years ago by an Egyptian peasant who moved here after a family feud then married several local women.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

And yet, even after you sequence the exomes of several family members (affected and unaffected) the causal variant or gene remains elusive.

Formally trained assistance or service dogs can have several trainers or handlers in their early lives, but after being placed, typically spend the rest of their lives with a single handler, providing assistance to the handler while also offering relief and comfort to other family members.

My special interest in climate change began several years ago when the child of a family member cried himself to sleep after watching a television documentary on the subject.

I have family members who are cops, I've been on numerous ride - alongs, and more importantly, I've asked them about this after buying them several rounds of shots at the bar to loosen them up.