The phrase
"after spinal cord injury" refers to a situation where an individual has experienced some form of damage or trauma to their spinal cord.
Full definition
Short - term peripheral nerve stimulation may be a new approach to preventing long - term changes in nerve and muscle function and improving rehabilitation
outcomes after spinal cord injuries.
Simply put, this could mean restored activity and ability in parts of the body that stopped working
after spinal cord injury in the near future.
This image depicts extension of human axons into host adult rat white matter and gray matter three
months after spinal cord injury and transplantation of human induced pluripotent stem cell - derived neurons.
New research in mice indicates that a drug commonly used to suppress the immune system in recipients of organ transplants may also reduce tissue damage and neuropathic
pain after spinal cord injury.
«Interneurons can
reroute after spinal cord injuries, which makes them a promising therapeutic target,» said senior author Todd McDevitt, PhD, a senior investigator at Gladstone.
Neuronal survival within spinal cord gray matter was determined using NeuN immuno - reactivity as a marker of surviving spinal cord neurons after spinal cord injury [34].
This work shows for the first time that IL - 37 suppresses the inflammatory
response after a spinal cord injury and minimises spinal tissue degeneration and functional disabilities.
The CSNE is now recruiting more participants with challenges using their hands and
arms after spinal cord injury, and the center will continue to test this novel form of stimulation as an innovative approach to improving hand and arm function.
They also had less nerve cell death and lower levels of proteins known to induce
inflammation after spinal cord injury and worsen neural damage (Neurobiology of Disease: DOI: 10.1016 / j.nbd.2010.04.003).
«Pressure ulcers are an unfortunately common
complication after spinal cord injury and cause discomfort and functional limitations,» said co-author Gwendolyn A. Sowa, M.D., Ph.D., associate professor of physical medicine and rehabilitation, Pitt School of Medicine.
Rapamycin treatment four
hours after spinal cord injury significantly improved locomotor function and reduced mechanical and thermal hypersensitivity in the hindpaws.
In their previous work, investigators at the Tohoku University Graduate School of Medicine in Japan found that rapamycin treatment can reduce nerve damage and locomotor
impairment after spinal cord injury.
Neuroscientists found that spinal blood flow in rats was unexpectedly compromised
long after a spinal cord injury (chronically ischemia), and that improving blood flow or simply inhaling more oxygen produces lasting improvements in cord oxygenation and motor functions, such as walking.
He also showed in 2012 that paralyzed rats could
recover after spinal cord injury after a few weeks of rehabilitation, combining electro - chemical stimulation and physiotherapy that uses a robotic harness.
To understand what molecules were potentially responsible for this remarkable process, the scientists conducted a molecular fishing expedition of sorts, searching for all of the genes whose activity abruptly
changed after spinal cord injury.
Oligodendrocyte death,
occurring after a spinal cord injury, activates a process called de-myelination that results first in damage to surviving neuronal connections and finally in death of the affected neurons.
A new study in mice published in The Journal of Neuroscience details a potential therapeutic strategy that uses stem cells to promote recovery of motor
activity after spinal cord injury.
Researchers demonstrated that susceptibility to spontaneous pneumonia and severe
lymphopenia after spinal cord injury resulted from a maladaptive sympathetic - neuroendocrine reflex involving the adrenal glands.
Stylized representation of a newly - discovered signaling pathway
active after spinal cord injury, which sees the injured central nervous system use adrenal hormone production to potentially disrupt the immune system in a way that lead to severe infections.
Building upon previous research, scientists at the University of California, San Diego School of Medicine and Veteran's Affairs San Diego Healthcare System report that neurons derived from human induced pluripotent stem cells (iPSC) and grafted into
rats after a spinal cord injury produced cells with tens of thousands of axons extending virtually the entire length of the animals» central nervous system.
WASHINGTON — Paralyzed rats can breathe a sigh of relief: A new treatment can restore lung function, even a year and a
half after a spinal cord injury that takes it away.
The discovery of motor pattern generators, the neural networks underlying movements, in the spinal cord is already being used to re-establish locomotion in people
paralysed after spinal cord injury.»
Bao, F., Brown, A., Dekaban, G.A., Omaña, V. and Weaver, L.C. Anti-CD11d integrin blockade reduces the systemic inflammatory response
syndrome after spinal cord injury.
Dr. Dyson - Hudson is presenting the model system's research on preventing
pneumonia after spinal cord injury, as well as results of a pilot study on the use of platelet - rich plasma therapy for shoulder pain in wheelchair users with spinal cord injury.
Bao, F., Bailey, C.S., Gurr, K.R., Bailey, S.I., Rosas - Arellano, M.P., Dekaban, G.A., and Weaver, L.C. Increased oxidative activity in human blood neutrophils and
monocytes after spinal cord injury.
Dr. Fyffe is a co-author of a related article, «Longitudinal analysis of
hospitalization after spinal cord injury: Variation based on race and ethnicity,» published online on August 2 by Archives of Physical Medicine & Rehabilitation (DOI: 10.1016 / j.apmr.2014.07.399).
The discovery of motor pattern generators, the neural network's underlying movements, in the spinal cord is already being used to re-establish locomotion in people
paralyzed after spinal cord injury.»
Reported MRI data from the SCiStar study that indicates AST - OPC1 cells have durably engrafted in patients post-implantation, demonstrating the potential for AST - OPC1 to prevent lesion cavity formation and possibly reducing spinal cord tissue
deterioration after spinal cord injury.
Previous studies of neuron survival by the Priestley lab have confirmed with toluidine blue histochemistry that NeuN immuno - reactivity is a reliable marker of neuron
survival after spinal cord injury [34].