Sentences with phrase «after transplantation»

«We need to have strategies for T - cell - mediated, or chronic, rejection,» Ayares said, which usually occurs within a few days after transplantation.

«We found that the diabetic mice were able to normalize their blood glucose levels for over a year after the transplantation of as few as 100 of these islets,» said Dr. Hiromitsu Nakauchi, a professor of genetics at Stanford, in a statement.

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells, EBioMedicine, in press.

An illustration showing the integration of neurons transplanted into the brain following injury, two months after transplantation.

Representative immunohistochemistry of GFP - positive fibers in transplanted muscles at two weeks after transplantation.

While most of these tumor models recapitulated specific types of breast cancer, Ding said the scientists were surprised to see that two of the 24 tumors evolved into a completely different type of cancer after transplantation into the mice.

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells.

(D) Histopathology of tongue, liver, lung, small intestine, and colon of vehicle and VPA recipients 30 d after transplantation (original magnification × 100).

Adenovirally generated induced pluripotent stem cells mediate a preservation of motor function or behavioral recovery after transplantation in a mouse model of Huntington's Disease

Rapamycin is an immunosuppressant drug which can be used to help prevent organ rejection after transplantation.

But Hescheler says his recent work proves that bone marrow cells will not differentiate into cardiac cells after transplantation.

«Having a very efficient and practical way of generating patient - specific stem cells, which unlike human embryonic stem cells, wouldn't be rejected by the patient's immune system after transplantation brings us a step closer to the clinical application of stem cell therapy,» says Belmonte, PhD., a professor in the Gene Expression Laboratory and director of the Center of Regenerative Medicine in Barcelona, Spain.

A new noninvasive urine test can distinguish among different causes of acute kidney dysfunction after transplantation.

Kollman C, Howe CW, Anasetti C, et al., Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age.

Final goal of Immune - mediated diseases Unit is to better understand immune - mediated diseases (i.e., autoimmune type 1 diabetes, or T1D, and rejection of tissues / organs after transplantation) and to define new approaches for their prevention and / or treatment.

By using a humanized sickle cell anemia mouse model, we show that mice can be rescued after transplantation with hematopoietic progenitors obtained in vitro from autologous iPS cells.

A total of 100 patients survived 20 years or more after transplantation.

Organ and patient survival rates were not different at one and three years after transplantation between the three groups.

Previous studies in mice have shown, however, that even genetically identical iPS cells can trigger an immune response after transplantation.

However, Eggan and McCarroll emphasized that now that this phenomenon has been found, inexpensive gene - sequencing tests will allow researchers to identify and remove from the production line cell cultures with concerning mutations that might prove dangerous after transplantation.

In an original article in Deutsches Ärzteblatt International, Hendrik Suhling and coauthors report the findings of the first study ever performed in Germany on the percentage of lung - transplant patients who resume employment after transplantation and the reasons that keep the others from going back to work.

In the younger patient, the left hand took 10 months, and the right 26 months, to work efficiently with the brain, leaving the patient with the left as his dominant hand when performing complex tasks after transplantation.

Luznik and colleagues have sought the right balance by giving high doses of cyclophosphamide, a chemotherapy drug with immunosuppressive effects, shortly after transplantation.

If rejection occurred in those with mostly IgG4 antibodies, it was usually much later after transplantation.

This achievement shows that human kidney glomeruli made in vitro can connect to blood vessels after transplantation and grow to maturity.

Patients with mostly IgG3 donor - specific HLA antibodies had a higher likelihood of organ rejection soon after transplantation.

Mice were on the high - fat or lower - fat diet for four weeks before transplantation and maintained on the same diet after transplantation.

Skeletal muscle cells isolated using the ERBB3 and NGFR surface markers (right) restore human dystrophin (green) after transplantation significantly greater than previous methods (left).

The disease often comes back after transplantation of a kidney, a condition called recurrence.

However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of highly aggressive tumors in immunodeficient mice after transplantation under the kidney capsule.

One of the surviving patients needs permanent intensive care, and has so far undergone nearly 8000 surgical interventions after the transplantation of the synthetic trachea.

«They had at least three divisions after transplantation,» Shetty said.

The researchers also demonstrated the adaptation of this strategy to kidney bud formation using embryonic kidney cells, and resulted in the formation of integrated glomerular - like tissues after transplantation.

A new study outlines the design and generation of a fluorescent induced pluripotent stem cell line for tracking cells post-differentiation after transplantation, describing problems and solutions along the way.

By means of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].

Analysis of the sample can determine if a kidney donor (potential live kidney donor or deceased kidney donor) or a patient inherited two APOL1 gene renal - risk variants that contribute to poorer renal allograft survival after transplantation.

We performed histological examination of GVHD target organs (liver, lung, small intestine, and colon) and the tongue, which served as a surrogate for skin damage (37), 4 wk after transplantation.

Even so, later time points are needed to ensure that tumors never form within the retina after transplantation of hNPCctx.

Genetic testing might help determine if a donor kidney carries greater risk for renal complications after transplantation, such as a higher serum creatinine concentration or earlier allograft failure.

No leukemia growth was observed in mice receiving TCD - BM + spleen T cells, indicating a potent GVL effect, but these mice developed severe GVHD after transplantation (Fig. 5B — D).

Persistent survival of the transplant was not required in order to obtain benefit after transplantation, as behavioral recovery was as extensive in animals in which transplanted cells were still present at 5 weeks as in those in which no human cells were detected at this time point.

We found that, in the allogeneic group, IFN - γ +, IL - 17A +, and IFN - γ / IL -17 A double - positive CD4 + T cells derived from spleen (Fig. 2A, 2B) and MLN (Supplemental Fig. 1A, 1B) increased since the early stage after transplantation compared with the syngeneic group, whereas the IFN - γ — and / or IL - 17A — producing CD8 + T cells increased only at the late stage (Supplemental Fig. 1C, 1D).

For Western blot assay and immunoprecipitation analysis, CD4 + T cells were isolated from mice spleen on day 21 after transplantation using a Mouse CD4 + T Cell Isolation Kit (Miltenyi Biotec), and the procedures were performed as described previously (35).

Furthermore we analyse their functionality in vitro, and in vivo after transplantation of iPS - RPE into the dystrophic RCS rat: a model of retinal dystrophy where the primary defect, originating in RPE cells [26], leads to blindness as a consequence of rod and cone photoreceptor degeneration [27]--[29].

The color allows the scientists to track the stem cells inside the mouse brain after transplantation.

The major limitation of this study is the rejection of human iPS - RPE after transplantation into the RCS rat.

Patients on the waiting list for KTX reported a significantly lower quality of life and more psychological distress than patients after transplantation.

We then treated BMT recipients with VPA or vehicle and recovered donor T cells from spleen and MLN of recipients on the indicated days after transplantation.

In tests in mice, the genetically engineered stem cells stuck around for at least four months after transplantation, an important benchmark to ensure that any potential therapy would be lasting.