These studies have been questioned as the genetic variant required for narcolepsy protects
against autoimmune type 1 diabetes.
Not exact matches
This could help scientists understand
autoimmune diseases, where the immune system turns
against normal body tissues, such as in
Type 1 diabetes and multiple sclerosis.
The researchers now hypothesize that microbes in the gut, where most of this pTreg cell population is switched on, may be responsible for generating these protective cells and thus protecting
against the
autoimmune attack on pancreatic beta cells that cause
type 1 diabetes.
In their latest work, reported online in the Journal of Clinical Investigation, the scientists analyzed blood from such mice and identified two
types of
autoimmune response directed specifically
against the protein, with the first response directed by a specialized kind of immune system cells called T cells and the second by antibodies.
The researchers were looking to specifically stop the
autoimmune response that causes
type 1 diabetes without damaging the immune cells that provide protection
against infections — what is called an «antigen - specific» immunotherapy.
It is estimated 20 percent of people with
type 2 diabetes also have an
autoimmune reaction
against the cells of their pancreas, prompting researchers to dub this «
type 1.5 diabetes.»