Sentences with phrase «against malaria parasites»

In 2012, James and colleagues reported that they had engineered Anopheles stephensi mosquitoes with genes that produce antibodies against malaria parasites.

Esvelt believes that immunizing mosquitoes against the malaria parasite, a positive application of CRISPR - Cas9, is a better place to start than eradicating a species with a lethal gene drive.

Not exact matches

Researchers at Stanford University purified the proteasome from the malaria parasite and examined its activity against hundreds of different peptide sequences using a novel method developed at the University of California, San Francisco.

This structure (bottom left) of the malaria parasite's proteasome, obtained using the revolutionary Cryo - Electron Microscopy technique, enabled the design of a specific inhibitor (front) against the mosquito - borne malaria parasite (pictured at back).

The 2015 Nobel Prize in Physiology or Medicine goes to William C. Campbell and Satoshi Ōmura for their discoveries of a medication against roundworm parasites and to Youyou Tu for her discoveries concerning a novel therapy against malaria.

Strains of drug - resistant tuberculosis are on the rise in Eastern Europe and Central Asia, and malaria has roared back as one drug after another has become ineffective against the parasite.

And the skeptics point out that vaccine developers have had little success against pathogens like HIV that routinely outwit the immune system — the malaria parasite, hepatitis C virus, and the tuberculosis bacillus are prime examples.

«Potent parasite - killing mechanism of anti-malarial drug uncovered: New understanding of how artemisinin works could facilitate development of new drugs and therapeutic strategies against malaria.»

A team of researchers from the National University of Singapore (NUS) has uncovered the mystery behind the potent parasite - killing effect of artemisinin, a drug that is considered to be the last line of defence against malaria.

We've already moved away from using quinine to treat cases as the malaria parasite has become more resistant to it, but if further drug resistance were to develop against our most valuable malaria drug, artemisinin, we would be facing a grave situation.

A study by researchers from the National University of Singapore has uncovered the mystery behind the potent parasite - killing effect of artemisinin, a drug that is considered to be the last line of defense against malaria.

«The ability of MMV048 to block all life cycle stages of the malaria parasite, offer protection against infection as well as potentially block transmission of the parasite from person to person suggests that this compound could contribute to the eradication of malaria, a disease that claims the lives of several hundred thousand people every year,» said Professor Chibale, Founder and Director of H3D, founding Director of the South African Medical Research Council (SAMRC) Drug Discovery Research Unit at UCT, and senior author of the paper.

Medical researchers have developed a new treatment against drug - resistant strains of the Plasmodium falciparum parasite that causes malaria.

A new paper published in the journal Science Translational Medicine describes the discovery and biological profiling of an exciting new anti-malarial clinical drug candidate, MMV390048, effective against resistant strains of the malaria parasite, and across the entire parasite lifecycle, with the potential to cure and protect in a single dose.

«When you consider that 200 million people across the world are infected with malaria and each of them is harbouring parasites that are continually generating millions of antigenic variants, it becomes apparent why our fight against malaria is so challenging,» says Professor Dominic Kwiatkowski, who leads MalariaGEN and is head of the Malaria Programme at the Wellcome Trust Sanger Insmalaria and each of them is harbouring parasites that are continually generating millions of antigenic variants, it becomes apparent why our fight against malaria is so challenging,» says Professor Dominic Kwiatkowski, who leads MalariaGEN and is head of the Malaria Programme at the Wellcome Trust Sanger Insmalaria is so challenging,» says Professor Dominic Kwiatkowski, who leads MalariaGEN and is head of the Malaria Programme at the Wellcome Trust Sanger InsMalaria Programme at the Wellcome Trust Sanger Institute.

«A global disaster,» predicts another, contemplating what could happen if malaria parasites worldwide developed resistance against the new artemisinin - based combination therapies (ACTs) that have become the gold standard.

A Singapore - India collaborative research project between the Singapore University of Technology & Design (SUTD) and CSIR - National Chemical Laboratories (NCL) completed phenotypic screening of a large collection of potent chemical inhibitors (known as MMV Malaria Box), against pathogenic parasites Toxoplasma gondii and Plasmodium falciparum, causative agents of human toxoplasmosis and mMalaria Box), against pathogenic parasites Toxoplasma gondii and Plasmodium falciparum, causative agents of human toxoplasmosis and malariamalaria.

A group of new drugs against malaria does more than just kill parasites; it may also restore the efficacy of a generation of older drugs called quinolines to which parasites around the world have become resistant.

In 2002 he learned of the dire need for synthetic artemisinin, a compound derived from the sweet wormwood plant, which is 90 percent effective against the parasite that causes malaria and has few side effects (malaria kills some 3 million people a year).

But several studies have suggested that mosquitoes engineered to build defenses against malaria are less fit than insects that chose to live with the parasites.

A human vaccine against malaria has faltered in the face of the sophisticated life cycle of Plasmodium falciparum, the one - celled parasite responsible for the most severe form of the disease.

«As drug resistance is a major problem for malaria control and eradication, it is critical that that we continue to develop new antimalarials that act against previously unexploited targets in the parasite to keep priming the drug pipeline.»

Scientists have been working for decades to develop a vaccine against malaria, but the Plasmodium parasite is a formidable foe.

In work that has spanned more than a decade, the researchers analyzed blood from adults living in malarial regions of Africa and eventually traced the protection to antibodies against a previously unknown malaria parasite protein called MSP3.

Most other vaccine trials have tried to use the malaria parasite — rather than the body's reaction against it — to find possible targets for vaccines.

There is no approved vaccine against the protozoan malaria parasite,

However, until an AMA1 malaria vaccine demonstrates clinical efficacy against genetically diverse natural parasites, the relevance of growth inhibition assays and other humoral and cellular immunogenicity endpoints for clinical development decisions will remain a matter of reasoned conjecture.

An ingredient commonly found in toothpaste could be employed as an anti-malarial drug against strains of malaria parasite that have grown resistant to one...

An experimental vaccine poised to win World Health Organization approval as the first to even partially protect children against malaria works better against one strain of the disease - causing parasite than others.

In a huge boost to the global fight against malaria, researchers have discovered how the malaria parasite protects itself by building resistance against the last - line in antimalarial medications, and how a new medical treatment can overcome the parasite's defences.

Regardless of artemisinin's effectiveness against malaria and other diseases caused by parasites and despite its anti-tumour potential, its usage faces a problem: the low content produced by the plant and the high cost of its chemical synthesis result in a scarce and expensive drug.

The coming year will see the widespread testing of the first effective vaccine against Plasmodium falciparum, the parasite that causes the most deadly type of malaria.

Happily, given its significance in developing countries, the paper, «Antibodies to PfSEA - 1 block parasite egress from RBCs and protect against malaria infection,» is not behind the Science subscription wall.