iPSC - NKs themselves have already shown efficacy in the battle against leukemia and HIV infection [4, 5] and so researchers from the laboratory of Dan S. Kaufman (University of Minnesota, USA) aimed to assess their anti-tumorigenic capabilities
against ovarian tumors [6].
Not exact matches
«Personalized
tumor vaccine shows promise in pilot trial: Vaccine
against patients» own
tumors triggers a broad response, and induced five - year remission in one patient with advanced
ovarian cancer.»
As proof - of - principle of the potential efficacy, Zhang's team grew human
ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the
tumors» growth using RNA interference
against FAL1.
A novel approach to cancer immunotherapy — strategies designed to induce the immune system to attack cancer cells — may provide a new and cost - effective weapon
against some of the most deadly
tumors, including
ovarian cancer and mesothelioma.
The chronically stressed mice had decreased immune function and experienced
tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of
ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack
against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.