Sentences with phrase «against sickle cell»

Working in human cells, Liu and coworkers used adenine base editing to correct a point mutation that causes the iron - storage disorder hemochromatosis and to install mutations that protect against sickle cell anemia.

Those mutations are known to protect against sickle cell anemia.

Not exact matches

The mutation that causes sickle cell anemia most probably became dominant because it gave some protection against malaria — but at a cost of its own.

Individuals who carry sickle cell trait (the unexpressed mutation of sickle cell anemia) are more likely to survive malaria and therefore, the trait is actually protective against a disease that is endemic in many parts of the world.

It could be a more complicated version of the familiar case of sickle cell anemia: having two mutant copies of a certain gene causes the disease, whereas having only one mutant copy provides protection against malaria.

By contrast, women who carry a sickle - cell allele, which protects against malaria, have only about 50 percent more surviving children in malaria - infested regions than women lacking the variant.

The classic example is the sickle cell gene — people with one copy of the gene are strongly protected against malaria but those with two copies of the gene develop a life - threatening condition known as sickle - cell disease.

Despite strong selection against the sickle - cell gene, 10 to 20 percent of Africans are carriers.

Similarly, carriers in the Jackson study of one copy of the genes that cause sickle - cell disease — a useful trait against malaria in Africa — appear to be more at risk for kidney disease.

The A and B blood groups (chromosome 9) protect against cholera; the cystic fibrosis and Tay - Sachs (15) mutations may protect against tuberculosis; the sickle - cell (11) and thalassemia (16) mutations protect against malaria.

Kwiatkowski and his team suspect that the variation might be subject to something called balancing selection — just like the sickle cell variation — where genes are selected because of their ability to protect against malaria, but are kept from becoming too common because of their potential downsides.

Individual LJI scientists have made very significant strides against three inflammatory diseases in particular, namely coronary artery disease, lung disease and sickle cell disease.

What can you say about a film that so swears about its cerebralism as to discuss sickle cell anaemia at some length, and then picturises a disturbing sequence of a 14 - year - old being admired by two sexual predators against an astonishingly and unironically sunny number?