Working in human cells, Liu and coworkers used adenine base editing to correct a point mutation that causes the iron - storage disorder hemochromatosis and to install mutations that protect
against sickle cell anemia.
Those mutations are known to protect
against sickle cell anemia.
Not exact matches
The mutation that causes
sickle cell anemia most probably became dominant because it gave some protection
against malaria — but at a cost of its own.
Individuals who carry
sickle cell trait (the unexpressed mutation of
sickle cell anemia) are more likely to survive malaria and therefore, the trait is actually protective
against a disease that is endemic in many parts of the world.
It could be a more complicated version of the familiar case of
sickle cell anemia: having two mutant copies of a certain gene causes the disease, whereas having only one mutant copy provides protection
against malaria.