Sentences with phrase «against the melanoma cells»

«Mensacarcin has potent anticancer activity, with selectivity against melanoma cells,» Loesgen said.

Not exact matches

An immunofluorescence image of a melanoma cell stained with antibodies against the cytoskeleton components indicate their invasion into surrounding matrix.

The Dartmouth team, led by Mary Jo Turk, Ph.D., established the crucial role of resident memory T cells in the skin in eliciting a strong protective response against melanoma.

«Molecule identified that helps give resident T cells in the skin their anti-cancer punch: The molecule CD103 is key to the long - term residence of T cells in the skin and to their potent anti-tumor response against melanoma.»

Discuss how mouse models can be used to study human immune responses against leukemia (using primary or genetically modified leukemia cells) and melanoma

BMH - 21 first jumped out, Laiho said, demonstrating potent action against melanoma and colon cancer cells.

They used the gene - editing CRISPR / Cas9 technique to sift the genomes of melanoma cells for changes that made tumors resistant to being killed by immune T cells, which are the main actors in the immune system response against infections and cancer cells.

«However, our results clearly show that natural killer cells can also carry out a long - lasting and effective immune reaction against the body's own pigmented cells, including malignant melanoma cells,» says Prof. Dr. Gunther Hartmann, Director of the Institute of Clinical Chemistry and Clinical Pharmacology of the University of Bonn.

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor - reactive T cells directed against overexpressed self - derived differentiation antigens after a nonmyeloablative conditioning regimen.

He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of the particular type of tumor they have.

If melanoma cells can be made to produce IL - 2, this should stimulate a strong, specific immune response against them.

As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.

James P. Allison and Matthew Krummel demonstrate that a monoclonal antibody directed against the CTLA - 4 molecule in a mouse model of melanoma could result in the rejection of tumors and that this rejection also resulted in immunity to a second exposure to tumor cells.

Two clinical trials that used antibodies to block PD - 1 and PD - L1, a related molecule that binds to PD - 1, resulted in significant and long lasting responses against melanoma skin cancer, renal cell (kidney) cancer, and lung cancer.

Sunscreens protect against sunburn, but there is no evidence that they protect against basal cell carcinoma or melanoma.