Sentences with phrase «against the tumors as»

Not exact matches

Pre-clinical studies have shown that ALT - 803 activates the immune system to mobilize lymphocytes against tumor cells and could potentially serve as an important component in combination treatments.

Chemotherapy aimed at killing single cells may not work as efficiently against bands of spreading tumor cells, she said.

Dr. Joaquín Espinosa is enthusiastic about the results of his study, «The constant activation of the Interferon response could explain many aspects of Down syndrome, such as cognitive deficit, stunted growth, increased prevalence of autoimmune disorders, high risk of Alzheimer's disease, and protection against solid tumors.»

After years of speculation about the promise of cancer vaccines as a way to use the immune system against tumors, the United States will soon see its first cancer vaccine hit the market.

Different classes of MHC molecules exist and are involved in immunity against pathogens and tumor cells as well as the formation of immune tolerance to self - antigens.

Advances such as a new understanding of cancer as a genomic disease and successes with immunotherapy — harnessing the immune system to thwart tumors — mean that «the time is right for a renewed surge against cancer,» they write.

Some types of innate immune cells, such as natural killer cells, can actually protect against tumor growth.

By viewing this fusion as another disease imposed onto tumor cells, scientists could devise new therapies against metastasis, the researchers say in the May Nature Reviews Cancer.

Investigated as a cancer treatment for many years, the molecule didn't turn out to be very effective against tumors, Hale says.

As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

Kwak has developed anti-cancer therapeutic vaccines to spark an immune system attack against tumors, but their effectiveness has been hindered by factors such as MDSCs that stifle immune response.

«Protein serves as natural boost for immune system's fight against infection, tumors.»

Looking forward, Gimi's work will focus on using these microencapsulated cells to stimulate the immune system to act against tumors, as well as activating drug synthesis.

They also showed that drugs against a type of breast tumor called HER2 positive breast cancer — such as the dual ERBB2 / EGFR inhibitor lapatinib — potentially could benefit more patients than currently receive them, if analysis of the tumor proteins is taken into consideration.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

Based on these studies, the authors are designing a clinical trial to test whether DNA repair inhibitors, such as olaparib, are active against IDH1 - and IDH2 - mutant tumors.

Searching for T cells that had infiltrated the tumors, they collected as many as 50 T cell samples from a single tumor; next, the team tested each batch of T cells against other tumor samples from the same patient.

More than 5,775 potential drug combinations, as well as each single drug, were screened against each cell line, looking for effects on the number and viability of tumor cells.

Immune checkpoint blockade has emerged over the past decade as a useful therapeutic tool against many types of tumors.

In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against human tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using xenograft mice as personal avatars for cancer patients was discarded.

As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotypAs demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotypas well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotypas some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotypas the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.

Their next steps are to characterize how these treatments affected NK cell function as well as determine the reactivity of patients» T cells against tumor mutations.

These research collaborations have the power to answer questions critical to improving cancer outcomes, such as how tumors develop drug resistance, and what treatments are most effective against particular genomic traits.

This is particularly important for vaccination against viruses and diseases such as cancer, in which T cells do not function strongly enough or fast enough to combat the growth of the virus or growth of the tumor cells.

The study conducted at SciLifeLab shows that temozolomide itself not only is cytotoxically active against glioblastoma tumors but also against other types of brain tumors, such as medulloblastoma and metastases from other primary tumors.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

An initial payload of CD8 cells breaks down the tumor, and the HSC - derived CD4 cleans up the remaining cells and acts as protection against the recurrence of any cancer cells expressing NY - ESO - 1.

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

Dual Approach Better for Liver Cancer A combined treatment for liver cancer that uses one oral drug and another delivered directly to tumors in a method known as chemoembolization appears to work better against liver cancer.

As several threads of knowledge coalesced into a unified idea, Stephan realized how, with a single device, he could bring the power of the immune system to bear against solid tumors like breast cancer.

Stephan's foggy early morning brainwave illuminated an unexpectedly simple approach to making cell - based immunotherapy, in which cancer - targeting immune cells are enlisted to fight tumor cells, as effective against solid tumors as it has been against blood cancers like leukemia.

one doctor's take on cancer: his thesis sees cancer as the body's defense mechanism against toxins by sequestering them in tumors

The chronically stressed mice had decreased immune function and experienced tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risas well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risas increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risAs we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.

We know that the lemony aura of limonene is more than just a scent, as it can be found in our blood after exposure.8 Furthermore, several anticancer cellular pathways appear to be affected by the terpene limonene, leading some to suggest it has anticancer, or chemopreventative, benefits.9 While feeding it to rats in studies has revealed some efficacy against breast tumors, 10 we have a ways to go before we can make such bold claims in humans.

As he pointed out in his groundbreaking book, What Your Doctor May Not Tell You About Breast Cancer, unopposed estrogen can break down the body's natural defenses against tumor growth.

Protect against breast cancer: Women who are genetically susceptible to breast cancer may benefit from higher vitamin D levels, as it interferes with the genetic pathway responsible for these types of tumors.

Alkalinizing effect on your body, which is thought to protect against disease, including cancer (as many tumors are acidic)

In fact, they stressed the fact of quercetin's effectiveness as a single agent against pancreatic cancer tumors, declaring: «Quercetin alone inhibited tumor growth to such an extent that it could not be further enhanced by the addition of gemcitabine.»

It may help protect against tumor development as well as act as a block enzymes associated with cancer, according to an article in Cancer Letters journal.

Too many vets are still vaccinating in the scruff of the neck - which has been strongly recommended against since the mid-1990s, since tumors that form there are inoperable; whereas a leg can be amputated when cancer invades there, as long as the vaccines are injected far enough away from the body.

Dogs are also helping advance the fight against human cancer as they serve as a model for various human tumors.

As a result, immune cells fail to recognize the cancerous tumor cells as a threat and they don't fight against theAs a result, immune cells fail to recognize the cancerous tumor cells as a threat and they don't fight against theas a threat and they don't fight against them.