«Scientists identify protein central to immune response
against tuberculosis bacteria.»
Not exact matches
Researchers at China's Northwest Agriculture and Forestry University devised a CRISPR / Cas 9 technique to give cloned dairy cows a leg up
against the
bacteria behind bovine
tuberculosis (Mycobacterium bovis).
While still far from being declared a true antibiotic drug, the compound teixobactin tested well in lab dishes
against Clostridium difficile, a microbe high on doctors» most - wanted list, as well as
against bacteria that cause anthrax and
tuberculosis.
Despite having been vaccinated
against the disease in 1989, which was 3 years before Sousa and her colleagues examined them, 58 % of the Indians had a weakened or nonexistent immune reaction in skin tests that measure cell response to the
tuberculosis bacterium.
In tomorrow's issue of the Proceedings of the National Academy of Sciences, researchers report that more than half of the Yanomami people who had been vaccinated
against TB do not produce a regular immune response to the
tuberculosis bacterium.
To learn how Mycobacterium
tuberculosis mounts a defense
against a drug, Baliga is first looking within the
bacterium, identifying the genes, proteins and other molecules that interact as the microbe infects a host.
In the test tube experiments, SMARt - 420 made ethionamide more potent in both ethionamide sensitive and resistant
bacteria, and it worked
against a wide range of M.
tuberculosis strains.
The compounds have been shown to be effective in killing many species of bacterial pathogens but are generally less effective
against the
bacterium that causes
tuberculosis.
Current treatments
against the
tuberculosis - causing
bacteria include prodrugs, such as ethionamide, which are activated by a bacterial enzyme.
In addition, when the scientists tested lansoprazole
against a wide range of other
bacteria, it proved to be highly selective for M.
tuberculosis.
The team identified 26 compounds that were active
against replicating
tuberculosis bacteria, 19 killed dormant
bacteria including seven that were active
against both.
«Even though humans mount a defense
against M.
tuberculosis that can contain its growth, in general that defense is insufficient to kill the
bacteria,» Dr. Shiloh explained.
The results could be useful in guiding the future design of novel medicines
against multidrug - resistant
tuberculosis, malaria, diabetes and antibiotic - resistant
bacteria.
Fennel appears to increase the efficacy of the antibiotic, streptomycin when used
against tuberculosis, although it shows no effect on the disease - causing
bacteria themselves.
Lungwort contains natural antibiotics in its acids which act
against the
bacteria that cause
tuberculosis, strep, staph, bacterial pneumonia, and other lung and chest infections.