Sentences with phrase «against tumor cells»

Since then, numerous studies have addressed the effects of these compounds against tumor cells in vitro, in vivo and in first clinical studies [3, 4].

Hu14.18 K332A is a laboratory - produced antibody designed to activate the immune response against tumor cells by recognizing and binding to an antigen found on the surface of most neuroblastoma tumor cells.

Pre-clinical studies have shown that ALT - 803 activates the immune system to mobilize lymphocytes against tumor cells and could potentially serve as an important component in combination treatments.

Drugs That Ramp Up the Immune System against Tumor Cells are Revolutionizing Cancer Treatment

Drugs that targeted the RAS pathway showed little activity against the tumor cells.

The mouse model could also contribute to the further development of immunotherapies — a method in which the body's immune system is stimulated, so that it intensifies its fight against tumor cells.

The authors said their results, which they have made publicly available, constitute an invaluable resource to help clinicians predict which chemotherapies will be most effective against tumor cells with particular genetic mutations, and how to rationally combine therapies to prevent cancers from developing resistance.

Nivolumab is an antibody (a type of human protein) that is being tested to see if it will allow the body - s immune system to work against tumor cells.

The difficulty in using monoclonal antibodies against tumor cells is that most of the antibodies raised will be against immunodominant antigens — all the high - visibility proteins that the immune system recognizes.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

In this system, the dendritic cells are activated and targeted against tumor cells while remaining inside the patient's body.

Radiation therapy can help extend the lives of affected dogs, but also is ineffective against tumor cells that have metastasized.

They discovered that treatment with the TIM - 3 antibody causes dendritic cells to produce chemical messengers which subsequently activate T cells, thereby resulting in an immune - mediated response against tumor cells.

«Tumor rejection requires both innate and adaptive immune responses against tumor cells.