Sentences with phrase «against tumors in»

«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»

While both the ketogenic and modified high - fat, low - carbohydrate diets showed similar effectiveness against tumors in the mouse models, Reynolds said the latter is more nutritionally complete and potentially more appealing to cancer patients because it offers more food choices.

An important approach in advanced cancer medicine is to treat cancer using a patient's immune cells after first arming the cells against the tumor in culture.

Not exact matches

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

Unlike Ruth Levy, whose lung cancer caused her no physical pain, Mr. Smith's tumor pressed against his spine and kept him in agony much of the time.

Cancer: Flaxseed may protect against breast cancer, prostate cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cells.

While the latter has a reputation for being hard to isolate, she explains that even degraded RNA generally contains enough intact sequence to analyze — provided investigators can detect the scarce tumor signals against the immense background of other RNA molecules in a sample.

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

They then tried adoptive T cell therapy (ACT), in which T cells directed against a tumor are infused into a patient.

The discovery of a treatment capable of blocking the mechanism responsible for the formation of metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against tumor metastasis.

Pre-clinical studies have shown that ALT - 803 activates the immune system to mobilize lymphocytes against tumor cells and could potentially serve as an important component in combination treatments.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

Published in the February 27 issue of Cell, the study found that tumor cells that reach the brain — and successfully grow into new tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic invasion.

C. novyi is really a two - pronged weapon against cancer: It germinates in tumors and releases cancer - killing enzymes, and it may also trigger an immune response similar to Coley's Toxin.

This gene is known to be highly active in multiple myeloma and many other cancers, raising the possibility that strategies to shut it down could be effective against a variety of tumors.

«Personalized tumor vaccine shows promise in pilot trial: Vaccine against patients» own tumors triggers a broad response, and induced five - year remission in one patient with advanced ovarian cancer.»

Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft tissue.

When researchers screened a library of more than 200 drugs and related compounds for activity against embryonal subtype tumor cells from three patients, the most promising results involved drugs that increased oxidative stress in tumor cells.

Swanton came up with similar results in three other patients, suggesting that optimum treatment for one region of a tumor might not be effective against another region.

Different classes of MHC molecules exist and are involved in immunity against pathogens and tumor cells as well as the formation of immune tolerance to self - antigens.

There is plenty of anecdotal evidence out there claiming a link between cell phone use and cancer: Keith Black, chairman of neurosurgery at Cedars - Sinai Medical Center in Los Angeles, says that the brain cancer (malignant glioma) that killed O. J. Simpson's attorney, Johnnie Cochran, was the result of frequent cell phone use, based on the fact that the tumor developed on the side of the head against which he held his phone.

In the second step, the precise substance would be found selected from the catalog that would be the most effective weapon against the specially particularly enriched tumor facet.

The mouse model could also contribute to the further development of immunotherapies — a method in which the body's immune system is stimulated, so that it intensifies its fight against tumor cells.

These lesions normally remain dormant, but a steady dose of cancer promoters in the diet may override natural defenses against the growth of tumors.

Principal Investigator John Morris, MD, clinical co-leader of the Molecular Therapeutics and Diagnosis Program for the CCC, co-leader of the UC Cancer Institute's Comprehensive Lung Cancer Program, professor in the division of hematology oncology at the UC College of Medicine and UC Health medical oncologist, says a number of antitumor vaccines have shown promise for causing immune responses against tumor antigens to improve patient outcomes.

One promising strategy in the fight against cancer is to use the body's own immune system to remove tumor cells, but due to a phenomenon called immune tolerance, the immune system has a difficult time identifying which cells to attack.

By viewing this fusion as another disease imposed onto tumor cells, scientists could devise new therapies against metastasis, the researchers say in the May Nature Reviews Cancer.

Now, scientists have modified Salmonella bacteria to trigger a particularly powerful immune response against human cancer cells implanted in mice, shrinking the tumors and — for the first time — preventing them from metastasizing.

Immunotherapy, the hottest field in cancer research, seeks to supercharge the body's natural defenses against deadly tumors.

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal modeIn their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal modein Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal modein an animal model.

As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

The intervention, he says, essentially trains the immune system to recognize and attack the tumor, and to protect against additional tumor formation — a significant issue in colon cancer.

In a 2011 vaccine trial of patients whose primary pancreatic tumors were surgically removed, «we found antibodies against annexin A2 in those who had received the vaccine and who also had demonstrated long - term, disease - free survival after receiving the vaccines,» explains ZhenIn a 2011 vaccine trial of patients whose primary pancreatic tumors were surgically removed, «we found antibodies against annexin A2 in those who had received the vaccine and who also had demonstrated long - term, disease - free survival after receiving the vaccines,» explains Zhenin those who had received the vaccine and who also had demonstrated long - term, disease - free survival after receiving the vaccines,» explains Zheng.

«Radioimmunotherapy not only worked against these cancers but, in addition, the radioactivity was confined entirely to the tumor masses, leaving healthy tissues undamaged,» said senior study co-author Ekaterina Dadachova, an associate professor of nuclear medicine and of microbiology and immunology at Einstein.

Because it more effectively induces cancer cell apoptosis in p53 - deficient tumors, FL118 is especially effective against late - stage cancers, which usually lose functional p53 and are resistant to DNA - damage drugs.

Lutz and Falkowski cite one study where unique chemical compounds isolated from an actinomycete strain inhabiting deep - sea sediments about 3.3 kilometers down in the South China Sea have shown potent activities against three cancerous tumor cell lines and also showed antibacterial activities.

In a study using mice, the researchers found that using Dox and TRAIL in the pseudo-platelet drug delivery system was significantly more effective against large tumors and circulating tumor cells than using Dox and TRAIL in a nano - gel delivery system without the platelet membranIn a study using mice, the researchers found that using Dox and TRAIL in the pseudo-platelet drug delivery system was significantly more effective against large tumors and circulating tumor cells than using Dox and TRAIL in a nano - gel delivery system without the platelet membranin the pseudo-platelet drug delivery system was significantly more effective against large tumors and circulating tumor cells than using Dox and TRAIL in a nano - gel delivery system without the platelet membranin a nano - gel delivery system without the platelet membrane.

They used the gene - editing CRISPR / Cas9 technique to sift the genomes of melanoma cells for changes that made tumors resistant to being killed by immune T cells, which are the main actors in the immune system response against infections and cancer cells.

«Novel imaging model helps reveal new therapeutic target for pancreatic cancer: Antisense treatment in preclinical models shows effectiveness against deadly tumors.»

Katiyar has published extensively in the past on other natural substances that work against tumors, especially skin cancer.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

These types of engineered tumors are much more difficult to treat than human tumors implanted in mice, because they suppress the immune response against them.

«If our findings are confirmed by additional studies, they may open doors to the development of targeted therapies against the tumor subtypes more likely to affect African Americans and potentially help reduce racial disparities in breast cancer.»

Researchers are hopeful that the approach they used in this study of neuroblastoma may prove effective against some of the many other cancers also characterized by a surplus of MYC - family proteins in tumor cells.

«We found polyploidy in liver cells did not strongly affect the activity of some oncogenes, but it did protect against the loss of tumor suppressor genes.

«While the failure of these drugs against brain metastasis has often been attributed to the blood brain barrier, some agents are small enough to penetrate into the brain,» says Rakesh K. Jain, PhD, director of the Steele Laboratories of Tumor Biology in the MGH Radiation Oncology Department, co-senior author of the report published in Science Translational Medicine.

In 2008, he joined the group of Caetano Reis e Sousa at the Cancer Research UK (CRUK) London Research Institute and later joined the Francis Crick Institute, where he was awarded Marie Curie and EMBO long - term postdoctoral fellowships to investigate innate immune receptors and signaling pathways that trigger dendritic cell activation and drive T - cell responses against viruses or tumors.

Researchers used the mice to show that pemetrexed and gemcitabine worked against human group 3 tumors and that the drugs could be used in combination with existing chemotherapy agents to boost treatment effectiveness without undue risk.

The mice were developed in Roussel's laboratory and are a powerful tool for testing the effectiveness of drugs against human tumors.