Sentences with phrase «against tumors with»

These drugs mainly act against tumors with one or more specific alterations in their DNA.

Together the team will not only be able to provide clarity on which drugs are most effective against tumors with specific PI3K - pathway mutations, but how these specific mutations differentially affect how the pathway functions.

Now, the two - year, $ 1 million PCF Challenge Award will allow Hsieh and MSK co-primary investigators Dr. Yu Chen and Dr. Brett Carver to combine their expertise to determine which drugs are effective against tumors with specific mutations and identify biomarkers that will enable oncologists to pair prostate cancer patients with the most effective treatment regimens.

Chen, also an expert in the processes by which genes are turned on and off, has pioneered cutting - edge organoid systems that recreate prostate tumors and will allow the team to much more easily test the activity of various drugs against tumors with specific mutations.

Our job now is to figure out how to make immunotherapy effective against those tumors with small numbers of mutations.

Not exact matches

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

Generally scientists have thought autophagy protects against cancer, although some evidence suggests it can help tumor cells cope with nutrient scarcity and other stresses.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

«Personalized tumor vaccine shows promise in pilot trial: Vaccine against patients» own tumors triggers a broad response, and induced five - year remission in one patient with advanced ovarian cancer.»

Swanton came up with similar results in three other patients, suggesting that optimum treatment for one region of a tumor might not be effective against another region.

Advances such as a new understanding of cancer as a genomic disease and successes with immunotherapy — harnessing the immune system to thwart tumors — mean that «the time is right for a renewed surge against cancer,» they write.

The authors said their results, which they have made publicly available, constitute an invaluable resource to help clinicians predict which chemotherapies will be most effective against tumor cells with particular genetic mutations, and how to rationally combine therapies to prevent cancers from developing resistance.

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.

Engineered with special tumor - recognition molecules, Listeria prods the immune system into action, marshaling an attack against tumors that the body might otherwise be unable to combat.

«Immunotherapy, pembrolizumab, is active against mucosal melanoma tumors: And prolongs survival for patients with bladder cancer.»

The immune activation from the CAR cells was also met with resistance mechanisms, including an upregulation of immunosuppressive pathways which may work against the patient and for the tumor, the researchers found.

The researchers treated mice with two types of thymus tumor with each peptibody, a control peptibody and an antibody against Gr - 1.

New research out of the University of Michigan supports combining two approaches to fight back against gliomas: attacking the tumor with gene therapy while enhancing the immune system's ability to fight it, too.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

While single - agent treatment with either drug had limited effects against mesothelioma, treatment with both drugs significantly reduced tumor size and prolonged the animals» survival.

Researchers used the mice to show that pemetrexed and gemcitabine worked against human group 3 tumors and that the drugs could be used in combination with existing chemotherapy agents to boost treatment effectiveness without undue risk.

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor - reactive T cells directed against overexpressed self - derived differentiation antigens after a nonmyeloablative conditioning regimen.

«Agents that block the proteins — CDK4 / 6 inhibitors — have received Food and Drug administration approval for some patients with metastatic breast cancer, but they've also shown promise against others types of tumors in clinical trials.

To see whether these new particles could be effective against tumors, Youn and his team first injected them into the tail veins of four mice with brain tumors.

As demonstrated by the breadth of clinical trial involvement shown above, CCIR members are testing the utility of immune checkpoint blockade in lymphoma (shown by Dr. Allison to be effective against melanoma), genetic engineering in cell therapy (e.g., CD19, CXCR2, TGF - β DNR), and TLR agonists or IL - 2 in vaccine formulations as well as some novel combination therapies, such as the infusion of tumor - reactive lymphocytes from HLA - matched donors who were vaccinated with a lymphoma idiotype.

We are advancing the fight against these rare tumors by developing biological models to help with drug development and to share with scientists worldwide.

Splenocytes, ascites, and tumor cells were stained with a viability dye and Abs against CD4, CD8α, CD62L (MEL - 14), CD44 (IM7), and CD25 (PC61.5; eBioscience) and were analyzed by flow cytometry.

While much recent research has not been published in this area, there is actually a long history of studies that show: (1) there is a significant number of antigens shared between tumors and embryonic tissues (called «oncofetal antigens») and, consequently, antibodies made against tumors can also recognize embryonic tissues, and vice versa; (2) pregnancy confers some immunity against cancer (accompanied by antibody production against oncofetal antigens), not only against its occurrence but also against its growth; (3) similar to pregnancy, an immune response against cancer can be generated by vaccinating animals with embryonic tissues.

Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T - cell response against different types of tumors.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

«The end game is to take the guesswork out of chemotherapy, with a clinical test that will assess dozens of drugs and drug combinations against tumor samples from each patient.»

A phase I trial of ramucirumab, a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors (NCT02564198).

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

A phase I trial of ramucirumab, a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors -LRB-

The TCGA analysis showed tumors with PTEN loss in the background of BRCA1 / 2 deficiency had lower levels of cytolytic immune molecules and immune - activating pathways that would normally drive immune responses against tumors.

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

As several threads of knowledge coalesced into a unified idea, Stephan realized how, with a single device, he could bring the power of the immune system to bear against solid tumors like breast cancer.

Induction of immune responses in patients with b - cell lymphoma against the surface - immunoglobulin idiotype expressed by their tumors

The American Council on Exercise advises against wave therapy for those who are pregnant, have a history of seizures, blood clotting issues, tumors, or people with pacemakers.

The chronically stressed mice had decreased immune function and experienced tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.

Protect against breast cancer: Women who are genetically susceptible to breast cancer may benefit from higher vitamin D levels, as it interferes with the genetic pathway responsible for these types of tumors.

Take - Home Messages If short - term fasting is appropriate, it potentially may be an effective, inexpensive strategy to decrease side effects, suppress tumor progression, protect patients against the effects of chemo - toxicity, and further improve prognosis when used with chemotherapy.

Anthocyanin gives strawberries their red color and works together with other flavonoids protect against cancer and tumor growth.

Glucosinolates may help prevent cancer by helping to remove potential carcinogens from the body and increasing your body's defense against cancer with tumor suppressor proteins.

It may help protect against tumor development as well as act as a block enzymes associated with cancer, according to an article in Cancer Letters journal.

Only in the last half - hour do the usual Emmerich absurdities pile up: I laughed outright at the character who, past 65 and diagnosed with a massive brain tumor that will kill him within months, can not be stopped by a ferocious beating, being stabbed in the neck with a sharp implement, then being crushed against a wall by an SUV moving at a minimum of 30 mph.