Not exact matches
The notion that antisense oligonucleotides might inhibit the progression of genetic
diseases or tumor - causing
viruses dates back to the late 1970s, when legendary molecular biologist Paul Zamecnik and colleague Mary Stephenson demonstrated the method's viability
against the Rous sarcoma
virus.
The Centers for
Disease Control put out a warning last week that anyone traveling to Brazil should get vaccinated
against the
virus.
Man had made enormous strides in discovering the causes of
disease, and is still fighting a long - drawn - out battle
against such things as the incredibly minute
viruses, and the apparently arbitrary cell - degeneration known as cancer.
One of these, IgA, which is present in highest amounts in the first few days of life, contains many antibodies
against viruses, bacteria and other
disease - causing organisms.
Mothers can communicate with donors directly and request blood test results to help protect
against the spread of
disease and
viruses.
CHICKENPOX COMMON AMONG CHILDREN DESPITE VACCINE The highly contagious varicella - zoster
virus (VZV), commonly known as chickenpox, often affects children under age 12 and sometimes even after they have been vaccinated
against the
disease, Oneida County Health Department officials warned today following reports of an outbreak in Herkimer County.
The company has begun human testing of its mRNA drugs for cardiovascular
disease and cancer, and for vaccines
against the flu, Zika, and chikungunya
viruses.
When Thomas Monath, an expert on vaccines combating mosquito - borne
diseases, thinks about developing an inoculation
against Zika
virus, he has a major concern: Guillain — Barré syndrome.
Understanding this critical step of Zika
virus replication will help researchers develop antiretroviral drugs
against this spreading
disease afflicting the entire globe.
Remarkably, the researchers also found that blocking this protein in mice protected them from the lethal effects of dengue
virus infection, an important finding given that an effective vaccine
against dengue has remained elusive, partly because there are four serotypes of the
virus that cause
disease.
Because survivors of an Ebola infection would typically have produced effective antibodies
against the
virus (otherwise they wouldn't have survived), transfusions of their blood into a newly infected individual may help that person survive the often fatal
disease.
Despite years of trying, scientists still haven't created an HIV vaccine that can protect people
against the
virus, says Alan Aderem, a biologist at the Center for Infectious
Disease Research in Seattle.
«We observed rapid and durable protective immunity without adverse events, and so we think this candidate vaccine represents a promising strategy for the global fight
against Zika
virus,» said senior author Drew Weissman, MD, PhD, a professor of Infectious
Disease at Penn. «We hope to start clinical trials in 12 to 18 months.»
Scientists at Dana - Farber Cancer Institute have identified natural human antibodies
against the
virus that causes Middle East Respiratory Syndrome (MERS), a step toward developing treatments for the newly emerging and often - fatal
disease..
Johns Hopkins Bloomberg School of Public Health researchers say a new candidate vaccine
against respiratory syncytial
virus (RSV) made with a weakened version of the
virus shows great promise at fighting the
disease, the leading cause of hospitalization for children under the age of one in the U.S.
An experimental drug that shuts down construction of
virus - making factories could become a new weapon
against MERS and similar respiratory
diseases.
The struggle in Brazil shows that the fight
against the Zika
virus, and
against other
diseases transmitted by Ae.
Historically, vaccines
against viral
diseases have used live - attenuated (weakened)
viruses or inactivated whole
viruses to induce protective immune responses.
«This drug was not developed as an alternative to vaccination but rather as an additional weapon in our arsenal
against the
virus that may enable us to improve
disease management and rapidly silence outbreaks,» he says.
«Despite the delay in airborne precaution implementation, we suspect that high hand hygiene compliance, as a result of continuous implementation of proactive control measures
against various
viruses and multidrug - resistant organisms, protected frontline healthcare workers
against many challenges of emerging infectious
diseases.»
One of the vaccines, which is based on a recombinant vesicular stomatitis
virus expressing the glycoprotein of the Zaire strain of the Ebola
virus (VSV - ZEBOV), was recently shown to be extremely effective with 100 per cent efficacy
against the lethal Ebola
virus disease in WHO - funded studies carried out in Guinea and Sierra Leone.
«We need to do everything we can to find effective drugs
against the Zika
virus, as changes in travel and climate have caused more tropical
diseases to move into new parts of the globe,» said Kao, who has also spent 15 years studying the
virus that causes hepatitis C.
«Drugs approved to treat hepatitis C and compounds in development to treat other viral
diseases are prime candidates to use
against the Zika
virus,» Kao said.
«Thus, we can develop targeted strategies
against disease - causing
viruses.»
This goal of this study, led by Geisbert and Ian MacLachlan, executive vice president and chief technical officer of Tekmira Pharmaceuticals, was to determine whether it is possible to protect animals
against a lethal MARV - Angola infection when treatment was started at a point when animals have detectable levels of the
virus in their system and show the first clinical signs of
disease.
«Our compound has an antiviral effect
against all these
viruses,» said Michael Gale Jr., University of Washington professor of immunology and director of the UW Center for Innate Immunity and Immune
Disease.
Kang's primary research focuses on designing and developing effective vaccines
against viral
diseases such as influenza
virus and RSV, but he partnered with a university and research institutes in South Korea that wanted international collaborative projects to study if ginseng can be used to improve health and protect
against disease because of the potential benefit in fighting these
viruses.
The vaccine protects
against four common strains of the
virus, considered the most common sexually transmitted
disease in the United States.
In fact, TBK1 may also be a contributor to debilitating
diseases such as ALS (Lou Gehrig's
disease) and childhood herpes simplex
virus encephalitis, if its connection with ICOS somehow triggers B cell activation and specific antibody production
against the body's own cells in ALS or an excessive response to the invading
viruses in childhood encephalitis.
It can be a serious, life - altering and even fatal
disease and currently, there is no cure or drug treatment
against West Nile
virus, which has been widely spread across the U.S., Canada, Latin America and the Caribbean.
In a teleconference held by Nature today, Kobinger said it was «quite remarkable» that they could rescue infected animals that had advanced
disease, which he called «a very important step forward in the fight
against Ebola
virus.»
The study, published in Scientific Reports, demonstrated that animals injected with synthetic DNA engineered to encode a specific neutralizing antibody
against the dengue
virus were capable of producing the exact antibodies necessary to protect
against disease, without the need for standard antigen - based vaccination.
Poultry farmers routinely vaccinate
against the
disease, which keeps their flocks healthy but does not stop chickens from becoming infected and spreading the
virus.
In this month's issue of Nature Medicine, scientists show that the
virus causes the symptoms in much the same way as faulty genes do, suggesting that a single therapy could work
against the
disease.
When the researchers exposed chickens to lethal doses of the avian influenza
virus and the Newcastle
virus, birds inoculated with the recombinant vaccine produced antibodies
against both
viruses, offering protection
against both
diseases.
Despite decades of research decoding the influenza
virus — and great advances in treating and vaccinating
against the
disease — this infectious pathogen continues both to surprise and confound us
Presentation: «Nucleotide Prodrug GS - 5734 Is a Broad - Spectrum Filovirus Inhibitor that Provides Complete Therapeutic Protection
Against Ebola
Virus Disease in Infected Non-human Primates.»
Similar experiments were performed demonstrating that the purified human antibodies also protected immunosuppressed hamsters
against lethal
disease caused by Sin Nombre
virus.
More to the point, by genetically stripping dengue
virus of its ability to bind 14 -3-3 epsilon, Gack has generated a crippled
virus that can elicit a strong human immune response, providing a framework for rational vaccine design
against emerging infectious
diseases.
This is particularly important for vaccination
against viruses and
diseases such as cancer, in which T cells do not function strongly enough or fast enough to combat the growth of the
virus or growth of the tumor cells.
The study relates to a particular type of vaccine (killed)
against a particular
virus, influenza, though the findings might hold true for other killed vaccines and for those vaccines consisting only of proteins produced by GM in bacteria, yeast or insect cells,
against diseases such as hepatitis B (HBV) and human papilloma
virus (HPV, the causative agent of cervical cancer).
Evaluations of an inactivated whole
virus vaccine in ferrets and nonhuman primates and a
virus - like - particle vaccine in mice induced protection
against infection but challenged animals exhibited an immunopathologic - type lung
disease.
The pathogens that cause
disease — parasites,
viruses, bacteria — are continually evolving to evade the human immune system, and to resist the vaccines and drugs that are used
against them.
Taken together, these studies suggest that a mechanism that exists to defend
against viruses also has an effect on whether or not the bacteria cause
disease in humans — an important finding that may help us better understand why only some of these bacteria lead to illnesses such as pneumonia and meningitis.
Eisen also said that while rising temperatures caused by climate change could bring the mosquito farther north in the United States, the many elements that influence the mosquito itself and the transmission of dengue
virus argue strongly
against looking solely at climate to assess
disease threat.
Dengue fever and West Nile fever are mosquito - borne
diseases that affect hundreds of millions of people worldwide each year, but there is no vaccine
against either of the related
viruses.
As vaccine recipients, we usually think only of the ability of the vaccine to protect us
against a specific
disease, but here the effects on the whole population and on the influenza
virus itself are being considered.
ANN ARBOR, Mich. — Dengue fever and West Nile fever are mosquito - borne
diseases that affect hundreds of millions of people worldwide each year, but there is no vaccine
against either of the related
viruses.
The powerful probiotics in the nut cheeses will nurture intestinal micro flora, heal the gut, and re-colonize intestines with organisms that defend
against disease,
viruses, and yeast.
«Influenza yearly protection is important for preventing the flu,» said Spicehandler, who is co-chief of infectious
diseases at Northern Westchester Hospital in Mount Kisco, N.Y. «Each year the vaccine is made up of different strains to protect
against what
viruses are prevalent.»