Sentences with phrase «age of human tissues»

DNA methylation age of human tissues and cell types.

Two general mechanisms have been proposed to explain the aging of human tissue.

Not exact matches

Malfunctioning mitochondria can cause problems in every cell in the body, contributing massive stress to our internal environment, increasing inflammation, rapid breakdown of tissues, and eventually degeneration of the human body (AKA rapid aging).

Regenerative medicine represents a new frontier in science, which seeks to understand the mechanistic basis of tissue aging, repair, and regeneration and to leverage this knowledge to improve human health.

Now Yamanaka and his colleagues report in the journal Cell that the same combination of genes induced pluripotency in commercially available human fibroblasts (connective tissue cells that play a crucial role in healing) derived from the facial skin of a 36 - year - old woman, the joint tissue of a man, aged 69, and a newborn, respectively.

There is a lot of work still to do, and many potential pitfalls before it could be applied to human patients, but in principle almost any illness caused by damaged or ageing tissue — heart disease, diabetes, Alzheimer's and dozens of others — could be fixed this way.

The gradual shrinking of telomeres negatively affects the replicative capacity of human adult stem cells, the cells that restore damaged tissues and / or replenish aging organs in our bodies.

Historically, animal models — from fruit flies to mice — have been the go - to technique to study the biological consequences of aging, especially in tissues that can't be easily sampled from living humans, like the brain.

There are two types of fat in humans: white adipose tissue, which makes up nearly all the fat in adults, and brown adipose tissue, which is found in babies but disappears as they age.

MDI Biological Laboratory Associate Professor James A. Coffman, Ph.D., is studying the regenerative capacity of sea urchins in hopes that a deeper understanding of the process of regeneration, which governs the regeneration of aging tissues as well as lost or damaged body parts, will lead to a deeper understanding of the aging process in humans, with whom sea urchins share a close genetic relationship.

That includes Melov's own study of seniors that revealed strength training exercise reverses aging in human skeletal tissue.

The framework of the study can also be applied to other bodily tissues to potentially provide a more holistic view of the aging process throughout the human body.

The technique, which requires genetic engineering, can not be applied directly to people, but the achievement points toward better understanding of human aging and the possibility of rejuvenating human tissues by other means.»

On the other hand, there are many other tissues — notably, the kidney and articular cartilage — where p16Ink4a - expressing senescent cells appear to be a contributing factor to human and murine degenerative aging, but which were not evaluated in treated or control mice in this study, and it would be of interest to see the effects of ablation of p16Ink4a - positive senescent cells.

During this Cell Symposium, we will delve into the fascinating mechanistic and physiological complexities of exercise biology at the cellular, tissue, and systemic levels and explore how exercise improves human health, including in disease settings and during aging.

Epidemiological surveys in humans indicate that muscle aging influences the progression of several age - related diseases in other tissues.

Even if glcosepane's low tissue burden in rats means that cleaving it will not have dramatic rejuvenating effects in these animals (which is a reasonable prediction, but might be happily disproven in the event), its high prevalence in aging and diabetic human collagen, and its implication in the complications of diabetes, will make the mere demonstration of a candidate's ability to cleave glucosepane crosslinks in vivo a sufficient proof - of - concept to spur further work to move it down the therapeutic pipeline into human testing.

«By learning how organisms such as the zebrafish can regenerate damaged tissues and applying these lessons to humans, scientists at MDIBL are increasing our understanding of how we might one day slow and potentially reverse the degenerative effects of aging.

Epidemiological surveys in humans indicate that muscle aging influences the progression of several age - related diseases in other tissues... >> MORE

In addition, further understanding of the processes during human development will shed light on the processes of ageing and how tissues repair themselves, which could lead to advances in regenerative medicine.

The aim of his research was to use microarray gene expression data in order to characterize ageing in different human tissues and identify the age at which major changes in genetic expression profiles occur.

Human cells undergo a process called cellular aging that limits the number of times they can divide, thereby setting the self - renewal capacity of human tisHuman cells undergo a process called cellular aging that limits the number of times they can divide, thereby setting the self - renewal capacity of human tishuman tissues.

By studying them, we are beginning to gain insight into human disease — to understand why organs such as the heart can not repair themselves or why, as we age, the incidence of debilitating diseases such as cancer, heart disease and Alzheimer's increases so rapidly, and we are developing new therapies that will enhance our abilities to regenerate damaged tissues and prolong healthy lifespan.

In addition, further understanding of the processes during human development will shed light on the processes of aging and how tissues repair themselves, which could lead to advances in regenerative medicine.

Although it is difficult to extrapolate from rats to humans, we may try to use our results obtained at the tissue level in rats to interpret our previous observations obtained only at the whole - body level in elderly women (5,6,18), i.e., comparing the responses of liver and muscle protein synthesis to the pulse feeding pattern in the 2 age groups could suggest that there was also a positive effect of the pulse pattern at the muscle level in humans.