Not exact matches
And a variety of studies are looking
at what role the breakdown of tryptophan may play in
aging and
age -
related diseases.
Finally, on September 30th, the New York Times reported on a telephone survey of over 1,000 former NFL players conducted by the University of Michigan's Institute for Social Research and commissioned by league which found, alarmingly, that former players were being diagnosed with Alzheimer's or similar memory -
related diseases at a rate 19 times higher than the normal rate for men
aged 30 through 49.
The Centers for
Disease Control and Prevention recommends the influenza vaccine for everyone over 6 months of
age, especially as kids under 5 years are
at highest risk for complications
related to the flu.
«A sedentary lifestyle increases the propensity to
aging -
related disease and premature death,» researchers
at King's College London report today in the journal Archives of Internal Medicine.
-- we could «identify novel drugs able to combat
age -
related diseases in completely new ways and thereby shorten the period of chronic illness experienced
at the end of life.»
Then she moved to her current position as principal scientist of a group that studies Alzheimer's
disease and
age -
related macular degeneration
at San Francisco's Rinat Laboratories, which is owned by Pfizer.
Next I was a European female.This time I was
at risk for
age -
related macular degeneration, atrial fibrillation, rheumatoid arthritis, and Crohn's
disease.
Dr Schneck and coauthors add, «The most common
age -
related eye
diseases (glaucoma,
age -
related macular degeneration, and diabetic eye
disease) all produce blue - yellow color vision anomalies,
at least in the preclinical or early stages.»
Overwhelmingly, scientists favor treatments that will slow
aging and stave off
age -
related diseases rather than simply extending life
at its most decrepit.
The results, if confirmed, could enable doctors to better prevent those ills for which the lonely are
at greater risk, such as heart
disease, infection,
age -
related dementia, and certain types of cancer.
Most research looks
at aging in older people, but the seeds of
age -
related diseases are planted decades earlier — that's why these researchers believe it's crucial to study
aging in the young.
«The older African American population is growing
at a rapid pace, and the burden of
aging -
related cognitive impairment and Alzheimer's
disease will continue to present a tremendous challenge,» said Lisa Barnes, PhD.
«And if there are more 85 - year - olds, it's almost certain there will be more cases of
age -
related diseases,» says Ken Langa, professor of internal medicine
at the University of Michigan.
«Increasingly, researchers are asking whether there is an
age -
related decline in autophagy and if it's connected to
diseases that occur more frequently in older individuals,» says Malene Hansen, Ph.D., professor in the Development,
Aging and Regeneration Program
at SBP.
As noted in the study by Crimmins and lead author Morgan E. Levine, assistant professor
at the Yale Center for Research on
Aging: «A deceleration of the human aging process, whether accomplished through environment or biomedical intervention, would push the timing of aging - related disease and disability incidence closer to the end of life.&r
Aging: «A deceleration of the human
aging process, whether accomplished through environment or biomedical intervention, would push the timing of aging - related disease and disability incidence closer to the end of life.&r
aging process, whether accomplished through environment or biomedical intervention, would push the timing of
aging - related disease and disability incidence closer to the end of life.&r
aging -
related disease and disability incidence closer to the end of life.»
«Current efforts to develop therapies against
age -
related diseases target these disorders one by one,» says Dr. Dan Ehninger, research group leader
at the DZNE site in Bonn.
Professor Clive Ballard from the Wolfson Centre for
Age -
Related Diseases
at the IoPPN, King's College London, said: «Our findings clearly indicate serious risks associated with antipsychotics and highlight the need for greater caution in treating psychosis in Parkinson's
disease.
Scientists
at the Stowers Institute for Medical Research have made a surprising finding about the aggregates of misfolded cellular proteins that have been linked to
aging -
related disorders such as Parkinson's
disease.
According to Sinclair, all of the mammalian SIRT genes (and their proteins) are possible drug targets for therapies aimed
at extending life, as well as staving off
age -
related illnesses, such as Alzheimer's
disease, cancers and metabolic disorders, like diabetes.
«Most studies of
aging look
at seniors, but if we want to be able to prevent
age -
related disease, we're going to have to start studying
aging in young people.»
One group, led by neurologist Teepu Siddique
at Northwestern University in Evanston, Illinois, searched for genetic markers in a Saudi Arabian family afflicted by a
related disease called juvenile primary lateral sclerosis (PLS) and in a Tunisian family with juvenile ALS, which appears before
age 25.
What's needed now is confirmation in other groups, says Bard Geesaman, a scientist
at Elixir Pharmaceuticals --- which develops drugs for
age -
related diseases — in Cambridge, Massachusetts.
As in prior studies among older adults, we found that obesity was associated with a decreased risk of dementia, consistent with the hypothesis that, while obesity in mid-life may increase risk for later - life cognitive decline and dementia, obesity
at older
ages may be associated with cognitive and other health advantages.25 - 27 The trend toward a declining risk for dementia in the face of a large increase in the prevalence of diabetes suggests that improvements in treatments between 2000 and 2012 may have decreased dementia risk, along with the documented declines in the incidence of common diabetes -
related complications, such as heart attack, stroke, and amputations.11 Our finding of a significant decline between 2000 and 2012 of the heart
disease -
related OR for dementia would also be consistent with improved cardiovascular treatments leading to a decline in dementia risk.
The Taub Institute for Research on Alzheimer's
Disease and the
Aging Brain
at Columbia University Medical Center is a multidisciplinary group that has forged links between researchers and clinicians to uncover the causes of Alzheimer's, Parkinson's and other
age -
related brain
diseases and discover ways to prevent and cure these
diseases.
Although of course there are a number of caveats since mice can be cured from cancer
at higher rates, they don't suffer from some of our
diseases, they are sensitive to being handled (if grabbing them can shorten their lifespan through stress, the mouse version of standard human medical care may do the same), so I guess that increases in maximum lifespan are indeed the only reliable indicator that an intervention is impacting
age -
related mortality.
The NIA provides information on
age -
related cognitive change and neurodegenerative
disease specifically at its Alzheimer's Disease Education and Referral (ADEAR) Center at www.nia.nih.gov/alzh
disease specifically
at its Alzheimer's
Disease Education and Referral (ADEAR) Center at www.nia.nih.gov/alzh
Disease Education and Referral (ADEAR) Center
at www.nia.nih.gov/alzheimers.
My research
at the MDI Biological Laboratory's Kathryn W. Davis Center for Regenerative Biology and Medicine is focused on identifying the genetic determinants of
aging and
age -
related degenerative
diseases.
Her project is aimed
at determining ways to decrease the severity and incidence of type 2 diabetes, an
age -
related disease.
Much of the research is still
at an early stage; but its potential applications include Parkinson's
disease, diabetes,
age related macular degeneration, and cartilage damage.
«Although FTD and NCL patients differ markedly in
age and clinical manifestations, we wanted to know if humans who carry FTD -
related genetic mutations in progranulin share features with NCL patients,» said Li Gan, PhD, associate director of the Gladstone Institute of Neurological
Disease and professor of neurology
at UCSF.
The new test is being used in research programs
at the UCSF Memory and
Aging Center, which employs advanced diagnostic techniques, including genetics, imaging, behavioral assessments, neurology, and neuropsychology to treat people with
age -
related brain
diseases.
At these meetings, members participate in panel discussions with faculty and other experts and develop ideas to promote the Buck Institute globally as a leader in research on
aging and
age -
related disease.
In my own lab here
at Indiana University School of Medicine, I am bringing some of those chemical biology techniques to bear on problems in eye
disease and we continue to work on tumors of the eye, but we also developed a major focus on neovascular eye
diseases, including wet,
age -
related macular degeneration (AMD).
Our research aims
at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering
disease - relevant targets that can be harnessed to drive drug discovery efforts in neurological and
age -
related neurodegenerative
diseases.
The research is aimed
at determining whether the reduced gene expression promotes healthspan and delays the onset of
age -
related diseases in the mice.
SENS Research Foundation supports research projects
at universities and institutes around the world with the goal of curing such
age -
related diseases as macular degeneration, heart
disease, cancer, and Alzheimer's
disease.
Researchers
at the Carolina Institute for Developmental Disabilities tracking
age -
related issues of autism identified an increased risk of Parkinson's
disease in this high - impact paper.
SENS Research Foundation supports research projects
at universities and institutes around the world with the goal of curing such
age -
related diseases as heart
disease, cancer, diabetes and Alzheimer's
disease.
«What we found is that negative perceptions on
aging are definitely significantly
related to [Alzheimer's]
disease indicators,» said study lead author Becca Levy, an associate professor
at the Yale School of Public Health in New Haven, Conn..
Ageing is just a natural process that might show up
at any
age and which is reflected not only by the modifications in our body appearance, but more importantly by the internal signs proving a gradual deterioration in our inner body ability to ensure an optimal metabolism and physiology, to keep a strong immune system and consequently to prevent and fight the chain of degenerative chronic
diseases, also called
age -
related diseases.
Here's a look
at the research that's been done on high - intensity interval training specifically in older adults with
age -
related illnesses like diabetes and heart
disease.
According to David Hogan, gerontologist, and professor of medicine
at the University of Calgary, examples of
age -
related diseases are:
Needless to say, strategies aimed
at treating sarcopenia and
age -
related diseases are needed.
Anti-aging medicine looks
at early detection, prevention and treatment of
age -
related diseases in the medical and reputable business communities.
The study looked
at some 8,846 people
age 50 and over who had been diagnosed with celiac
disease using an intestinal biopsy to confirm celiac -
related intestinal damage, and compared them to 43,474 people who didn't have celiac
disease.
Researchers have found that BDNF levels decline progressively with
age.10 Lommatzsch, M., et al. «The Impact of Age, Weight and Gender on BDNF Levels in Human Platelets and Plasma,» Neurobiology of Aging 26 (2005):... continue At the same time that BDNF levels decrease, the volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... conti
age.10 Lommatzsch, M., et al. «The Impact of
Age, Weight and Gender on BDNF Levels in Human Platelets and Plasma,» Neurobiology of Aging 26 (2005):... continue At the same time that BDNF levels decrease, the volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... conti
Age, Weight and Gender on BDNF Levels in Human Platelets and Plasma,» Neurobiology of
Aging 26 (2005):... continue
At the same time that BDNF levels decrease, the volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with
Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... conti
Age -
Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological
diseases, such as Huntington's and Alzheimer's
disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... c
disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's
Disease,» Journal of... c
Disease,» Journal of... continue
As scientists look
at aging and neurological
disease formation, and the issues
relating to declining cognitive abilities tied to those populations, they can't help but ask the question, «Could increasing BDNF levels naturally through something as simple as exercise have benefits
relating to cognitive functionality?»
While some are training for competitive athletic events, others
at the same
age are institutionalized with nutrition
related disorders, such as diabetes or heart
disease, or other disorders, such as dementia.
There are preventative tests that can be performed to catch problems
at an earlier
age and medications that can be used to help pets that are diagnosed with senior pet
related diseases.
Senior pets are also
at higher risk for
age -
related illnesses or
diseases.