Not exact matches
It is dominated by the far - seeing genius of Josh Boger, who at
age 7 does experiments in a
lab above his parents» garage (including sending a hapless
mouse soaring aloft on a Hindenberg - type contraption he rigs up).
«When this question came up, I said, «Well, I have no idea,»» recalls Bartke, because the
mice were always killed in the
lab's endocrinology experiments before reaching old
age.
The First International Symposium on Neurobiology and Neuroendocrinology of
Aging was held in 1992, and Bartke's lab presented some of its findings on aging in the giant
Aging was held in 1992, and Bartke's
lab presented some of its findings on
aging in the giant
aging in the giant
mice.
Lead author David W. Frederick, PhD, a postdoctoral fellow in the Baur
lab, and the team generated
mice in which they could restrict the amount of NAD in specific tissues in order to simulate this aspect of normal
aging in otherwise healthy
mice.
At PENN - PORT, Varamini worked in the research
lab of physiology professor Joseph A. Baur, studying the molecular mechanisms of
aging in transgenic
mice.
Last year in Cell, Wagers's and Lee's
labs reported that injections of GDF11 can reduce the thickening of the heart that typically comes with
aging in
mice.
«It was incredible to see that in adult
mice, who have gone through normal development and
aging, simply overexpressing Arc with a virus restored plasticity,» says co-first author Kyle Jenks, a graduate student in Shepherd's
lab.
Research in
mice, fruit flies, worms and other
lab organisms has turned up many potential causes of
aging.
A study by Stephen Abolins, Mark Viney and colleagues of the immune ecology of wild house
mice — the same species as the
lab mouse — shows that their immune state is promoted by individuals» body condition and constrained by their
age.
The idea that biological
age is measurable and predictive only recently moved out of the
mouse lab into human epidemiology.
Using a technique called parabiosis, in which the vascular systems of two
mice are surgically connected, Villeda's
lab had previously discovered that infusing old
mice with the blood of younger
mice leads to brain rejuvenation, including improvements in learning and memory, while infusions of old blood cause premature brain
aging in young
mice.
To see if those effects might explain the link between paraquat,
aging, and PD in living organisms, the team turned to genetically altered
mice that the Campisi
lab had developed for senescent cell studies.
In 2009, under the Interventions Testing Program of the National Institute of
Aging that also funded this research, the Harrison
lab reported that rapamycin significantly extends the lifespan of
mice, the first demonstration of a pharmaceutical intervention to do so in mammals.
C.C. Little, the inventor of the modern
lab mouse and founder of the Jackson Laboratory, had long used «the
age old enmity of woman and the Muridae» as a sales pitch for his model organism.