Sentences with phrase «aged mice causes»
«High folic acid intake in aged mice causes a lowered immune response.»
https://www.sciencedaily.com/ Not exact matches
The cardiovascular system, which often fails and causes early death in these prematurely aging mice, also showed improvements in structure and function.
Studying mouse monocytes in more detail, the researchers found that the increase in TNF levels that occurs with age causes premature release of immature monocytes from the bone marrow into the blood stream.
Research in mice, fruit flies, worms and other lab organisms has turned up many potential causes of aging.
In a new study in mice published in the Journal of Nutritional Biochemistry, scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (HNRCA) set out to determine if excess folic acid intake caused adverse changes in the immune system.
Their study in aged mice indicates that high folic acid intake causes lowered immune function because natural killer (NK) cells, a particular type of immune cell, are less effective.
«Something in aging [mutant] mice was causing the stem cell to lose its «stemness»,» says Fisher.
Here, we've caused age - related memory loss in the mouse, and we've shown it to be relevant to human aging.»
Using a technique called parabiosis, in which the vascular systems of two mice are surgically connected, Villeda's lab had previously discovered that infusing old mice with the blood of younger mice leads to brain rejuvenation, including improvements in learning and memory, while infusions of old blood cause premature brain aging in young mice.
To find out if the loss of Tet2 in aging could directly cause cognitive decline, the researchers used a technique called RNAi to block Tet2 activity in the hippocampi of young adult mice.
Beyond that, Dr. Andersen has shown in unpublished work (presented at the 2014 Rejuvenation Biotechnology Conference8) that eliminating senescent astrocytes confers similar benefits to mice with a model of PD that more closely mimics the fundamental processes that drive Parkinson's in aging people not suffering from either environmental toxicity or rare, genetic causes of PD.
BubR1 insufficiency causes early onset of aging - associated phenotypes and infertility in mice.
As the investigators note, the rapid age - related arterial stiffening and cardiac arrhythmias that appear to be at cause for the majority of deaths in BubR1H / H mice were not attenuated by ablating p16Ink4a - expressing senescent cells — but these tissues had little burden of such cells, so this finding reinforces the conclusion that the multiple aging phenotypes arrested in these mice when senescent cells were ablated is attributable specifically to the removal of their baleful influence on local tissues.
Thus, chronically increased p53 activity causes premature aging in mice, whereas transgenic mice with extra copies of p53 and ARF genes under normal regulation show tumor resistance and extended life span.
SAN FRANCISCO, CA — A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer's disease, improving cognition to normal levels in aged mice.
Scientists were able to identify the influence caused by factors unique to the blood of young mice, which could ultimately be used as treatments for age - related neurodegenerative disorders.
Plus, the unhealthy fats may make you more vulnerable to UV damage, which is the number - one cause of aging, according a preliminary mouse study published in Lipids.
Gene therapy in old mice has been shown to cause to a 27 % increase in strength, along with regeneration of aging muscle.
A recent study in mice showed that collagen destruction is the chief culprit causing age - related hair loss, but more studies are needed to warrant collagen supplementation for hair growth.4 Evidence is currently lacking on collagen supplementation for growing stronger nails, 5 so you're better off protecting your nails with a hardening clear coat and supplementing with biotin instead.