Sentences with phrase «aged mice displayed»

The researchers found that middle - aged mice displayed exaggerated pro-inflammatory responses after the first injection.

Not exact matches

In addition, it has been reported that median lifespan extension in CR heterozygote SIRT1 (±) mice was identical (51 %) to that observed in wild - type mice, but SIRT1 (±) mice displayed a higher frequency of certain pathologies 13 highlighting its important role in age - related diseases.

While 80 % or more of the 110 CAG mice displayed clasping from 8 weeks of age onwards, only 15 - 30 % of the 240 CAG mice displayed clasping at 14 - 18 weeks of age and a max of 70 % clasped at 19 weeks of age.

Behaviorally, the mice with 110 CAG repeats showed a sharp decline in both rotarod and open field performance from around 4 weeks of age whereas the 240 CAG repeat mice displayed a 2 - 3 week delay in the onset of behavioral decline with a much slower progression of decline in both tasks as compared to 110 CAG repeat counterparts.

Aged C3 - deficient mice also performed significantly better than WT mice in the contextual fear conditioning task, which evaluates memory associated with aversive stimuli, and C3 - deficient mice display reduced anxiolytic behavior, evaluated via the elevated plus maze and open - field assessment.

In line with the behavioral data, our whole brain TissueCyte ® based analyses suggests that younger mice (∼ 4 - 5 months) exhibit very sparse parenchymal plaques while aged mice (> 7 months) show a clear progression in the number / size of plaques and display differential increases in regional plaque load number / size.