Sentences with phrase «aged mice during»

Next, Abadir and colleagues compared the effects of different concentrations of losartan and valsartan on young diabetic and aged mice during the proliferation / remodeling phase of wound healing, which involves the regrowth of normal tissue.

Not exact matches

«We determined if a high - or low - fat diet, in combination with exercise and food restriction, impacted microglia during aging in mice.»

In rodents, differences in life expectancy and morbidity during aging are particularly high: Despite close relationships with regard to genetic aspects, small rodents like mice or rats live no longer than two to three years, whereas mole - rats or chinchillas have an average life span of 20 to 30 years while staying comparatively healthy.

Walford's new research is based on the fact that in mice and humans, the immune system malfunctions during aging, losing the ability to distinguish between healthy cells and invasive pathogens such as bacteria and viruses.

In one group of mice, he and his colleagues dosed their mothers with a synthetic compound that simulates a mild viral infection during late pregnancy; when their offspring hit early puberty at about 6 weeks of age, the young mice were exposed to unpredictable stress, such as being restrained, deprived of water, or given electric foot shocks.

Mice were sacrificed by CO2 asphyxiation at 20 — 21 weeks of age during the second and third hour of the light cycle.

Methods: R6 / 2 CAG 240 (peak training at 11 weeks of age), zQ175 knock in (KI) HET (peak training at 27 weeks of age) and BAC HD (peak training at 48 weeks of age), as well as respective age - matched wild type (WT) control mice, were trained on the peak interval task (20 s interval) in which response rates during unreinforced peak trials were examined.

A series of new mouse models have recently been developed in the laboratory that will allow us to dissect how DNA damage, oxidative stress and chromatin remodeling impact on mitochondrial integrity and stem cell decline during aging.

Telomere shortening induces cell intrinsic DNA damage checkpoints and cell extrinsic alterations that impair the stem cell function and maintenance during aging of telomere dysfunctional mice.

My research interest is using genetically modified mouse to study the DNA damage checkpoints in stem cells during aging.

In addition, studies performed across the lifespan in the tissues of mice appear to confirm that mutations do not accumulate substantially during the aging process per se in most tissues.

Analysis of exploration times during the test revealed significant object / age interaction (P = 0.0293, 3 - way ANOVA with age and treatment as between - subjects factors and object as within - subjects factors), indicative of preferential exploration of the object in the novel location by the younger animals and a lack of such preferential exploration in 20 - month - old mice.

Analysis of escape latencies (Figure 3B) during training indicated significant effects of aging and, possibly, rapamycin, such that escape latencies were increased in aged mice and were decreased by rapamycin treatment (P = 0.0021, P = 0.0548, and P = 0.2419 for age, treatment, and age / treatment interaction, respectively, 3 - way ANOVA with age and treatment as between - subjects factors and training day as within - subjects factor).

«Low - Calorie Diet Slows Aging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdAging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdiMice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdimice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdaging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdings.

At 8 months of age, both DIO and DR groups had increased hyperglycemic response during a glucose tolerance test, which was normalized in 16 - month - old mice.

Bored and cooped up, Thomas, age seven, teaches his four - year - old brother how to play Mouse Trap; Eva's father, during a typical before - school routine, must teach her to button a coat because she's only ever snapped one; and Claire, a veteran classroom teacher, skillfully turns a student's witty remark into an engaging way for her students to choose summer reads: speed - dating their books.