Sentences with phrase «aged mice indicates»

Their study in aged mice indicates that high folic acid intake causes lowered immune function because natural killer (NK) cells, a particular type of immune cell, are less effective.

Not exact matches

Sinclair thinks that these mouse models indicate that resveratrol may be effective in preventing age - related diseases in humans, like cancer, heart disease and type 2 diabetes.

«Our results indicate that the epigenetic modification we studied makes both mice and humans more susceptible to obesity and with increasing age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.

The researchers then confirmed that the number of singly paired chromosomes — also called univalents — was higher in older mouse and even human egg cells, indicating that age - related segregation errors could be tracked back to increased numbers of prematurely separated chromosome pairs.

Although we did observe positive effects on some aging traits, such as memory impairments and reduced red blood cell counts, our studies showed that similar drug effects are also seen in young mice, indicating that rapamycin did not influence these measures by slowing aging, but rather via other, aging - independent, mechanisms.»

But mice engineered to have hundreds of times more of these mutations than average showed no signs of premature aging, indicating that scientists are going to have to look elsewhere for their culprit.

The research, which was performed in mice, indicates that a mother's health, even before conception, may influence the health of her fetus, and opens questions on how a mother's age may influence placental development.

Significant differences between wt and XpdTTD / TTD but not between wt and XpdTTD / † XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks.

Intestinal inflammation in TNFΔARE mice is clinically indicated by weight loss and the disease fully develops by 8 weeks of age.

We observed no significant effect of genotype for any of these genes (data not shown), indicating that 7 - to 8 - month - old Grn − / − mice have not yet developed the elevated levels of inflammatory cytokines found at older ages (Filiano et al., 2013).

Additionally, we have previously detected decreased levels of respiratory chain proteins in the brains of aged Polg mutator mice from our colony, which would indicate mtDNA damage (Hauser et al., 2014).

In contrast, no Slc6a14 − / − female with PyMT transgene developed tumours at 3 months of age; however, at 4 months of age, small tumour nodules became detectable (Figure 2B), indicating a marked delay in mammary tumour development in PyMT - Tg mice as a consequence of Slc6a14 deletion.

Analysis of escape latencies (Figure 3B) during training indicated significant effects of aging and, possibly, rapamycin, such that escape latencies were increased in aged mice and were decreased by rapamycin treatment (P = 0.0021, P = 0.0548, and P = 0.2419 for age, treatment, and age / treatment interaction, respectively, 3 - way ANOVA with age and treatment as between - subjects factors and training day as within - subjects factor).

For example, results of a mouse study conducted by the National Institutes of Health (NIH) in collaboration with ChromaDex published in November 2014 indicated that NR was effective at restoring NAD + levels in mitochondria and rescuing phenotypes associated with a devastating accelerated aging disease known as Cockayne Syndrome (CS).