Sentences with phrase «aged mice showed»

Furthermore, examination of aged mice showed dramatically reduced levels of Cbf - beta in bone marrow cells, as compared to younger mice.

Not exact matches

In 2014, highly publicized work in the laboratories of Villeda and Tony Wyss - Coray, PhD, professor of neurology at Stanford, showed that connecting the circulatory system of a young mouse to that of an old mouse could reverse the declines in learning ability that typically emerge as mice age.

This image shows the discovery by researchers that induction of partial cellular reprogramming improved muscle regeneration in aged mice.

The cardiovascular system, which often fails and causes early death in these prematurely aging mice, also showed improvements in structure and function.

Shown are a mouse with a premature aging disease called progeria (left) and a mouse with progeria that got reprogramming treatments (right).

Mice that make extra of the protein show signs of premature aging.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

A low - fat diet in combination with limited caloric consumption prevents activation of the brain's immune cells — called microglia — in aging mice, shows research published today in Frontiers in Molecular Neuroscience.

«We also carried out behavioral assessments which showed the treated mice spent more time on running wheels than the mice who aged without intervention.»

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

In marked contrast to the widely held notion that the insulin - producing pancreatic beta cell loses function with wear and tear, the researchers now show that mouse and human beta cells are fully functional at advanced age.

The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans.

«Sleep - deprived mice show connection with diabetes, age.»

Longo also knew of research by molecular biologist John Kopchick at Ohio University, which showed that mice with a mutation in their growth hormone receptor gene lived 40 percent longer than normal mice — the equivalent of an average American living to age 110.

By examining first pregnancies in aged mice, the team showed that, for mice as for humans, the risk of complications increases with age.

«Gut microbes contribute to age - associated inflammation, mouse study shows.»

This report shows, however, that after only eight weeks of exercise, old mice experienced faster muscle repair and regained more muscle mass than those of the same age that had not exercised.

Strikingly, the germ - free mice did not show an age - related increase in intestinal permeability or in levels of bacterial products or pro-inflammatory cytokines in the bloodstream, in contrast to conventionally raised mice.

Although we did observe positive effects on some aging traits, such as memory impairments and reduced red blood cell counts, our studies showed that similar drug effects are also seen in young mice, indicating that rapamycin did not influence these measures by slowing aging, but rather via other, aging - independent, mechanisms.»

These mice start showing tau tangles at around 6 months of age and exhibit some neuronal damage by 9 months.

By the time this strain of genetically modified mice reaches 9 months of age, the hippocampus — a part of the brain important for memory — typically is visibly shrunken and shows dying neurons.

In the past five years, that compound, resveratrol, has been shown to slow aging in worms, flies, and mice.

According to the researcher, who is in the closing stages of her doctorate thesis, the measurements show that in several parameters mice expressing the risk factor for Alzheimer's «age» metabolically at a relatively young age.

Studies out this summer from Sinclair and others show that mice given resveratrol have reduced aging of the heart, slower cataract development, and better bone density.

A group of scientists led by Sebastian Jessberger of the Brain Research Institute showed now that also the stem cells of the adult mouse brain asymmetrically segregate aging factors between the mother and the daughter cells.

For researchers working on animal models, it shows that the age of male mice can influence the behavior of the offspring, so this should be a consideration when they are used to mate.

The researchers discovered that mice with genetic mutations that stop this endocannabinoid system from working properly age faster than normal mice, and show more cognitive decline.

When Yousef injected plasma from people in their late 60s into the bodies of 3 - month - old mice — about 20 years old in human terms — the mice's brains showed signs of ageing.

Nevertheless, the mutator mice showed no signs of premature aging, such as osteoporosis, balding, or reduced fertility, the team reported online 4 March in Nature Genetics.

But mice engineered to have hundreds of times more of these mutations than average showed no signs of premature aging, indicating that scientists are going to have to look elsewhere for their culprit.

«Earlier studies have shown that vitamin E can help regulate the aging body's immune system, but our present research is the first study to demonstrate that dietary vitamin E regulates neutrophil entry into the lungs in mice, and so dramatically reduces inflammation, and helps fight off infection by this common type of bacteria,» said first author Elsa N. Bou Ghanem, Ph.D., postdoctoral scholar in the department of molecular biology and microbiology at Tufts University School of Medicine (TUSM).

Next, the researchers gave the drug to older mice that already showed signs of aging, such as muscle loss.

Image analysis studies of the IAPP staining (Fig. 3 A) show that both the percentage of islets containing IAPP aggregates (Fig. 3 E) and the load of IAPP deposits (Fig. 3 F) in the Tg / Tg group of mice progressively increased with age.

The duration (20 minutes) used in the current study was based on previous work by our group demonstrating attenuation of age - related bone loss in male mice (36), but this duration is also less than the 60 - minute protocol shown to promote bone formation in the study by Jing et al. (44).

Conversely, Tg - hIAPP mice inoculated with WT pancreas homogenate (hereafter referred to as the Tg / WT group) only began to show small IAPP aggregates at around 20 wk of age (Fig. 3, A and B), in a manner similar to untreated Tg mice.

Groups of male Tg - hIAPP mice were injected i.p. at 3 wk of age with 10 % pancreas homogenate from either 12 - mo - old, male, IAPP Tg mice bearing substantial islet amyloid aggregates (as shown in Fig. 1) or from age - matched, male, WT mice not expressing hIAPP.

A study by Stephen Abolins, Mark Viney and colleagues of the immune ecology of wild house mice — the same species as the lab mouse — shows that their immune state is promoted by individuals» body condition and constrained by their age.

Here, we've caused age - related memory loss in the mouse, and we've shown it to be relevant to human aging.»

In mice predisposed to the disease, we showed that these fatty acids accumulate very early on, at two months of age, which corresponds to the early twenties in humans.

The first part of the study showed that giving birth multiple times was a significant contributor to obesity regardless of age, with mice who gave birth multiple times being up to 45 percent heavier than those who had a single litter at the same age that the first animals had their fourth.

Ageing XpdTTD / TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6 — 8 segment of the tail vertebrae counted from the pelvis (see close - up at right).

Researchers have shown that lowered levels of c - myc can modestly slow aging and extend life in mice, with some evidence that this is due to effects on insulin metabolism, though there is a still a lot of investigation needed to take that as a firm conclusion.

GDF11: Higher levels of GDF11 have been shown to improve numerous measures of aging in mice, such as heart function, exercise capacity, and sense of smell.

Oisín has shown as much as an 80 % reduction in senescent cells in cell culture and significant reductions of senescent cell burden in naturally aged mice.

This new study investigates this in old mice showing signs of age - related worsening of memory function.

Results from this two - day water maze show that AD mice take considerably longer to find the hidden platform on Day 2 than AD mice treated with J147 for three months (Figure 1A), demonstrating that J147 significantly improved the spatial navigational memory in aged, transgenic AD mice.

Mice that had been eating a ketogenic diet performed at least as well on memory tests at old age as they did at middle age, while mice eating the normal diet showed an expected age - associated declMice that had been eating a ketogenic diet performed at least as well on memory tests at old age as they did at middle age, while mice eating the normal diet showed an expected age - associated declmice eating the normal diet showed an expected age - associated decline.

In addition, 110 CAG mice exhibited tremors at rest at early ages, but the 240 CAG mice only showed tremors at later ages and only after manipulation.

Behaviorally, the mice with 110 CAG repeats showed a sharp decline in both rotarod and open field performance from around 4 weeks of age whereas the 240 CAG repeat mice displayed a 2 - 3 week delay in the onset of behavioral decline with a much slower progression of decline in both tasks as compared to 110 CAG repeat counterparts.

Aged mutant amyloid precursor protein mice with established disease showed a near complete restoration in levels of synaptic and neuronal proteins after exposure to young blood in parabiosis (synaptophysin P =.02; calbindin P =.02) or following intravenous plasma administration (synaptophysin P <.001; calbindin P =.14).