Sentences with phrase «aged mice with»

Vascular dysfunction in young, mid-aged and aged mice with latent cytomegalovirus infections.

In aged mice with diabetes (represented on the right), Tregs are overexpressed in fat tissue and trigger insulin resistance.

Not exact matches

Making that mistake is even more costly in an age of increasingly short attention spans and technological tools that make it easy to find some other diversion with a quick click of the computer mouse or the swipe of a finger on a smartphone.

Here she's posing outside No 10 with a selection of tiny knitted hats to support Help the Aged — we presume they're for the Downing Street mice Larry the cat has since failed to catch.

In The EMBO Journal, they reported that NAD levels decreased with age in the mouse hippocampus, a vital region of the brain for cognition.

Now, ageing mice have been given a new lease of life after being injected with a drug that jump - starts their mitochondria.

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This age period is associated with a decline in reproductive function and egg quality in both humans and mice.

To find out more about what underlies the cognitive decline that occurs with ageing, André Fischer of the European Neuroscience Institute in Göttingen, Germany, and colleagues analysed DNA from the brains of both young and old mice that had been set tasks involving learning and memory.

Shown are a mouse with a premature aging disease called progeria (left) and a mouse with progeria that got reprogramming treatments (right).

Additional research could make clear whether the post-natal role of huntingtin tapers off with age in humans in the same way that it does in mice.

Finally, mice in which the Hand2 gene was specifically deleted in the endometrium developed precancerous endometrial lesions with age.

Researchers have found that a diet enriched with omega - 3 helps repair and prevent retinal damage in mice, a discovery with potential for preventing blindness in premature infants and adults suffering from age - related macular degeneration.

«Our results indicate that the epigenetic modification we studied makes both mice and humans more susceptible to obesity and with increasing age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.

Part of the problem, he says, is that the incidence of many human chronic diseases rises with age, yet many researchers prefer using young mice because of the pressures of being published and getting funding.

In these mice and healthy controls, the time it took for levels of lactic acid in the brain to double correlated with how fast they aged.

Most recently, they have taken mice in late middle age and lengthened the remainder of their lives by an average of 30 to 40 percent with a drug called rapamycin, an antifungal agent also used to suppress immune responses in transplant patients.

«Caloric restriction in combination with low - fat diet helps protect aging mouse brains: Low - fat diet plus limited caloric intake prevented aging - induced inflammatory activation of microglia; exercise was significantly less effective than caloric restriction in preventing these changes.»

«We determined if a high - or low - fat diet, in combination with exercise and food restriction, impacted microglia during aging in mice.»

«Aging - induced inflammatory activation of microglia could only be prevented when mice were fed a low - fat diet in combination with limited caloric intake,» says Eggen.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

To the scientists» surprise, the mice that were dosed with cell phone radiation did not suffer from memory impairments as they aged — unlike their radiation - free counterparts.

A low - fat diet in combination with limited caloric consumption prevents activation of the brain's immune cells — called microglia — in aging mice, shows research published today in Frontiers in Molecular Neuroscience.

An MIT - led research team has now found that it can reverse this age - related endurance loss in mice by treating them with a compound that promotes new blood vessel growth.

GDF - 11, which regulates the growth of spinal and olfactory (smell) receptors, is produced abundantly in young mice, but production drops off with age.

Elderly mice suffering from age - related heart disease saw a significant improvement in cardiac function after being treated with the FDA - approved drug rapamycin for just three months.

Studying mouse monocytes in more detail, the researchers found that the increase in TNF levels that occurs with age causes premature release of immature monocytes from the bone marrow into the blood stream.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

«But after 16 to 18 weeks — the mouse equivalent of early middle age — we noticed that the male mice born to moms with fragmented sleep were eating more.

In marked contrast to the widely held notion that the insulin - producing pancreatic beta cell loses function with wear and tear, the researchers now show that mouse and human beta cells are fully functional at advanced age.

The researchers found that bone mass was severely reduced at eight weeks of age in the offspring of mice with vitamin B12 deficiency.

With increasing age, the proteins accumulate in the brains of fruit flies, mice, and humans.

And in 2001, molecular biologist Mark Sands at Washington University in St. Louis, Missouri, found a high rate of liver tumors in middle - aged mice that had been treated as newborns with a supposedly safer viral vector.

Last year in Cell, Wagers's and Lee's labs reported that injections of GDF11 can reduce the thickening of the heart that typically comes with aging in mice.

At young adulthood, Larsson's mice resembled those three times their age, with bone and muscle loss, heart disease — even baldness.

Its concentration was low and steady at young ages - within the known critical period for mice — and ramped up with age.

«Sleep - deprived mice show connection with diabetes, age.»

Longo also knew of research by molecular biologist John Kopchick at Ohio University, which showed that mice with a mutation in their growth hormone receptor gene lived 40 percent longer than normal mice — the equivalent of an average American living to age 110.

The mice with age - related disease, they found, had abnormally high levels of immune cells called T regulatory cells (Tregs) inside their fat tissue.

The new drug, in its time - release coating, was tested in mice with abnormalities similar to those experienced by people with neovascular age - related macular degeneration, or «wet» AMD.

By examining first pregnancies in aged mice, the team showed that, for mice as for humans, the risk of complications increases with age.

Ret is not an unknown factor for the Martinsried - based neurobiologists: «We already succeeded in demonstrating a few years ago in mice that neurons without the Ret receptor die prematurely and in greater numbers with increasing age,» says Klein.

In rodents, differences in life expectancy and morbidity during aging are particularly high: Despite close relationships with regard to genetic aspects, small rodents like mice or rats live no longer than two to three years, whereas mole - rats or chinchillas have an average life span of 20 to 30 years while staying comparatively healthy.

«It was incredible to see that in adult mice, who have gone through normal development and aging, simply overexpressing Arc with a virus restored plasticity,» says co-first author Kyle Jenks, a graduate student in Shepherd's lab.

Enter a mutant mouse strain that is afflicted at a young age with many of the diseases common to older humans.

But without SCF, the hair in mouse models was gray, and then turned white with age, according to the study.

Changes in muscle repair with aging were determined by injecting the old mice and young mice (neither group exercised) with snake venom commonly used to induce muscle injury in rodent studies.

Adult mice and humans can regenerate digit tips, although humans lose this ability with age, suggesting that regenerative abilities could be reawakened in mammals.

«It's still too early to see if this works in humans,» says Rafael de Cabo, an investigator at the National Institute on Aging who has collaborated with Sinclair and is testing some of Sirtris's compounds in mice.

With use of advanced mouse models, she and her team found that blood stem cells without adequate SIRT1 resembled aged and defective stem cells, which are thought to be linked to development of malignancies.