Compared to aged vector controls,
aged rats overexpressing FKBP1b showed dramatic enhancement of spatial memory, which correlated with marked reduction of sAHP magnitude.
Using microinjection of adeno - associated viral vector bearing a transgene encoding FKBP1b into the hippocampus of
aged male
rats, we assessed the critical prediction that
overexpressing FKBP1b should reverse Ca2 + - mediated manifestations of brain
aging.