Sentences with phrase «ageing related diseases such»

Such models aim to elucidate the contribution of single genes for protection against mutations, genomic instability, ageing and ageing related diseases such as cancer.

Numerous subsequent studies have confirmed that a calorie restriction of 30 to 60 percent of ad libitum intake increases the life span by similar amounts in a range of organisms including yeast, roundworms and rodents, while simultaneously decreasing or delaying the occurrence of age related diseases such as numerous cancers (including lymphomas, breast and prostate cancers), hypertension, stroke, diabetes, nephropathy, autoimmune disorders and other risks factors for cardiovascular disease (3,4).

Not exact matches

To this end, Calico has also forged a partnership with a Chicago - based biopharmaceutical company called AbbVie, in order to develop drugs that will tackle aging and age - related diseases such as neurodegeneration and cancer.

Demographers call this reduction in the typical span of age - related illness «the compression of morbidity» and attribute it primarily to improvements in the treatment of common ailments such as heart disease.

Spinach - A very nutrient - dense food - Loaded with flavonoids which act as antioxidants, protecting the body from free radicals - Helps keep the heart healthy - May slow the age - related decline in brain function - Its lutein protects against eye diseases such as age - related cataracts and macular degeneration

Such factors could potentially be altered to slow drift, having major impacts on age - related disease prevention.

Were that market to experience free fall, mayhem could ensue: Research has linked increased protein oxidation to age - related diseases such as cancer, heart disease, diabetes, and Alzheimer's and Parkinson's diseases.

Eye diseases — such as age - related macular degeneration, as well as a genetic condition called Stargardt's macular dystrophy that afflicts young people — are considered excellent candidates for stem cell therapy because the eye is an immune - privileged site, meaning transplanted cells are not as likely to be rejected as foreign compared with transplants elsewhere.

The study, published online ahead of print in The Journal of Clinical Investigation, has implications for treating diseases such as diabetic retinopathy and age - related macular degeneration — the leading causes of vision loss in adults.

The researchers found that, based on subjects» genetic profiles, the centenarians could be further divided into 19 subgroups, some of which were associated with delayed onset of age - related diseases such as dementia, hypertension and cardiovascular disease.

The results, if confirmed, could enable doctors to better prevent those ills for which the lonely are at greater risk, such as heart disease, infection, age - related dementia, and certain types of cancer.

This trend is certainly set to stay, with an ageing population and the emergence of lifestyle - related «epidemics» such as obesity, diabetes, asthma, and heart disease.

As life expectancy has increased, the burden of both normal age - related cognitive decline and neurodegenerative diseases such as Alzheimer's has become one of the biggest public health challenges worldwide.

Helen Thomson writes that transfusions of young blood may help treat age - related conditions such as Alzheimer's and heart disease (23...

Anti-aging proteins have long been shown to protect against age - related diseases, such as cancer, neurodegeneration, and cardiovascular disease.

In recent years, defective autophagy has been linked to age - related diseases such as cancer, neurodegeneration and heart disease.

Global complex problems, such as energy, environmental issues, pandemics or diseases related to aging societies, also have to be faced jointly by different disciplines.

The findings, published in JAMA Ophthalmology, point to critical interventions in the prevention and treatment of blinding eye diseases, such as age - related macular degeneration and diabetic retinopathy (DR), among Chinese Americans.

Common age - and diabetes - related retinal diseases, such as wet macular degeneration, also result in part from VEGF - driven processes, so ophthalmologists soon began to use Avastin «off - label» to treat these conditions.

«We study caloric restriction because it has such a robust effect on aging and the incidence and timing of age related disease,» says corresponding author Rozalyn Anderson, an assistant professor of geriatrics.

By understanding the underlying biology of aging, she notes, it may be possible to develop drugs in the future that will promote healthy aging and delay age - related diseases such as some cancers, arthritis, diabetes, high blood pressure and heart disease.

Although much research has examined traumatic brain injury (TBI) as a possible risk factor for later life dementia from neurodegenerative diseases such as Alzheimer's disease (AD), little is known regarding how TBI influences the rate of age - related cognitive change.

Many suspect this inflammation drives the early onset of aging - related conditions such as dementia and cardiovascular disease.

Scientists at the Stowers Institute for Medical Research have made a surprising finding about the aggregates of misfolded cellular proteins that have been linked to aging - related disorders such as Parkinson's disease.

According to Sinclair, all of the mammalian SIRT genes (and their proteins) are possible drug targets for therapies aimed at extending life, as well as staving off age - related illnesses, such as Alzheimer's disease, cancers and metabolic disorders, like diabetes.

Yet one - third of global health issues are related to neurological problems, such as depression, pain, and the diseases of the aging brain.

Telomere dysfunction — alterations in the structure and / or functioning of telomeres — is one of the molecular mechanisms underlying a number of age - related diseases but, to date, little is known about its possible role in pathologies of the liver such as cirrhosis, hepatitis and liver cancer.

Optical Coherence Tomography (OCT) is a high - resolution live imaging technique that can be used for early detection of retinal diseases, such as age - related macular degeneration, diabetes - related conditions, glaucoma or vascular occlusions, for example.

Potential new approaches to treating eye diseases such as age - related macular degeneration (AMD) are described in a new study, «IL - 33 amplifies an innate immune response in the degenerating retina,» in the February Journal of Experimental Medicine.

When the telomeres are worn away, the chromosomes become vulnerable to mutations, possibly paving the way for age - related diseases such as atherosclerosis and certain cancers.

People on Earth with eye problems related to aging, such as macular degeneration, and diseases, such as diabetic glaucoma, also would benefit.

Older mice seem to benefit from such an arrangement, developing healthier organs and becoming protected from age - related disease.

As in prior studies among older adults, we found that obesity was associated with a decreased risk of dementia, consistent with the hypothesis that, while obesity in mid-life may increase risk for later - life cognitive decline and dementia, obesity at older ages may be associated with cognitive and other health advantages.25 - 27 The trend toward a declining risk for dementia in the face of a large increase in the prevalence of diabetes suggests that improvements in treatments between 2000 and 2012 may have decreased dementia risk, along with the documented declines in the incidence of common diabetes - related complications, such as heart attack, stroke, and amputations.11 Our finding of a significant decline between 2000 and 2012 of the heart disease - related OR for dementia would also be consistent with improved cardiovascular treatments leading to a decline in dementia risk.

Inflammation plays a central role in vision - threatening eye diseases such as age - related macular degeneration and diabetic retinopathy.

LA JOLLA — A study tying the aging process to the deterioration of tightly packaged bundles of cellular DNA could lead to methods of preventing and treating age - related diseases such as cancer, diabetes and Alzheimer's disease, as detailed April 30, 2015, in Science.

The work opens up the possibility that the hypothalamus may be an important target in treating age - related diseases such as heart disease and Alzheimer's.

They have joined forces with CHS Pharma, Inc., a South Florida - based biotechnology development company that has an intellectual property portfolio for potential treatments related to ischemic stroke, dry macular degeneration as well as other age - related disorders such as Alzheimer's disease, to further develop and commercialize this promising technology.

Conversely, experiences that produce maladaptive changes in brain circuitry underlie many neuropsychiatric disorders, and age - related decreases in brain plasticity contribute to age - related memory disorders such as Alzheimer's disease.

Insufficient or excess complement activation has been shown to be important in a wide range of disease states, such as multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis, and age - related macular degeneration, as well as in allograft rejection.

In particular, common neurological conditions such as stroke, Alzheimer's disease, Parkinson's disease and other chronic neurodegenerative diseases, age - related cognitive impairment, epilepsy, mood disorders and schizophrenia call for new therapeutic strategies.

In retinal diseases such as age - related macular degeneration, for example, photoreceptor cells that absorb light signals are damaged or dead.

His research interests include the development of advanced ophthalmic imaging devices and their application to the study of human diseases such as glaucoma and age - related macular degeneration.

Future studies of these cells are expected to shed light on developmental diseases such as autism and schizophrenia and malformations of brain development, including microcephaly, lissencephaly and neuronal migration disorders, they say, as well as age - related illnesses, such as Alzheimer's disease.

Cardiovascular disease and renal disease for example are accelerated in patients with diabetes and AGEs have been shown to induce senescence in cell types related to these diseases, such as endothelial progenitor cells, vascular endothelial cells and renal cells.

They also argue that as long as patients with dementia are excluded from clinical trials of therapies for common age - related diseases, such as osteoporosis or arthritis, physicians will have insufficient data to make evidence - based recommendations for this rapidly growing group.

Dr. John Lewis's research interests lie in the areas of nanotechnology and imaging as they relate to the development of novel treatments for chronic diseases such as aging and cancer.

5/14/2008 Shiley Eye Center Noted for Excellence in Study Only Center in Nation to Receive Stand Out Award UCSD's Shiley Eye Center is receiving national accolades for its visionary approach to studying and treating age - related eye diseases such as macular degeneration.

We have previously shown that epigenetic modifications may accumulate during aging (5,6), and that DNA methylation in humans is influenced by diet, birth weight, and exercise (7 — 10), suggesting that epigenetics could be involved in age - related and life style — related diseases such as T2D.

Understanding the genetic basis of human age - related diseases, as well as normal aging, such as cardiovascular changes, age - related neurodegenerative disease, autoimmune disease, and diabetes constitutes an important step towards unraveling disease pathogenesis and risk prediction.

Following a period of intensive meditation, genes involved with the infectious cycle may get downregulated along with related host genes regulating protein synthesis, an explanation that is supported by other stress reduction interventions that have shown increased innate antiviral activity, such as upregulated Type 1 interferon activity.40 Shorter telomeres in population - based studies have been predictive of earlier onset of chronic diseases of aging, including diabetes, 41 cardiovascular disease9 and certain cancers.42