Sentences with phrase «agent model for»
This article aims to show that behavioral multi-agent models are a suitable approach for assessing the impact of policy instruments to reduce CO2 emissions in road transport by introducing a multi agent model for the German road transport sector.
https://www.transportation.gov/ Not exact matches
Until the company can move away from an ad - driven business model (which accounts for 90 percent of revenue), it will continue to make people's data available to advertisers and potentially bad agents.
FBI agents were also looking for documents in Cohen's possession related to payments made to another woman who claims she had an affair with Trump, Playboy model Karen McDougal.
For Tzell, that's been based largely on expanding its independent agent model into a form of consolidation that's really a partnership with other travel agencies, allowing it to leverage their volume without actually buying the partner's assets.
These «Blue Star» agents will be the first of their kind for MSI, and if successful, the model may scale across Marie Stopes» global system.»
OPP.Buzz Commercial Director, Paul Childs, says, «Agents should enquire now for the opportunity to sell commercial office space under the successful Bar Works model, now coming to San Francisco.
The Whiteheadian model thus leads to a metaphysical analysis which allows for the actions of a multiplicity of agents.
Today, conditions seem more fertile.Unlike the NASL, the 12th - year, 13 - club MLS has seven teams (and counting) playing in soccer - specific stadiums; four new national TV contracts; a countrywith 42 million Hispanics, many of them soccer lovers; a base of competitivehomegrown players feeding a U.S. team that has reached five straight WorldCups; and a single - entity business model that prevents teams from spendingthemselves into bankruptcy by bidding against each other for free agents.
And will someone tell Ted that you are allowed to use advanced stats and models that account for age in evaluating free agents?
You are role models and agents of change and you also contribute to the socio - economic development of this nation and for that the government recognizes all your efforts.»
During the 2014 Ebola outbreak in West Africa, for example, the Virginia Tech group used an agent - based model to help the U.S. military identify sites for field hospitals.
The downside is that models like NPS1 tend to be big — each of the model's initial runs kept a 500 - microprocessor computing cluster busy for a day and a half — forcing the agents to be relatively simple - minded.
In economics, agent - based models can be a powerful tool for understanding global poverty, says Stéphane Hallegatte, an economist at the World Bank in Washington, D.C..
The NPS1 model, for example, gets by with built - in rules that cause the agents to shift back and forth among just a few behaviors, such as «health care — seeking,» «shelter - seeking,» and «evacuating.»
«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.
«We know that 70 - 75 percent of glioblastoma patients undergo surgery for tumor debulking, and we have previously shown that MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking,» he continued.
Last January, state - of - the - art computer aided modeling enabled the researchers to identify an anti-cancer agent capable of deactivating a gene known to be essential for the metastatic spread of breast cancer.
«Our work and that of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study (ADCS).
The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.
The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.
But then Silicon Valley «invented the «free agent» model of hiring for new skills rather than training and then letting workers go once those skills aren't needed.»
Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.
«Exact formula now available for measuring scientific success: Polish team has developed equations governing the growth of authors» h - index using an agent - based model.»
One - year trial data were used to calculate cost - effectiveness for 1 year for the 3 anti-VEGF agents; mathematical modeling was then used to project 10 - year cost - effectiveness results.
The team increased one forcing agent (see sidebar) in a climate model, for example carbon dioxide, and decreased another, say methane, so that global mean temperature didn't change.
The heights of the rectangular bars denote best estimate values guided by published values of the climate change agents and conversion to radiative perturbations using simplified expressions for the greenhouse gas concentrations and model calculations for the ice sheets, vegetation and mineral dust.
(Top left) Global annual mean radiative influences (W m — 2) of LGM climate change agents, generally feedbacks in glacial - interglacial cycles, but also specified in most Atmosphere - Ocean General Circulation Model (AOGCM) simulations for the LGM.
The Animal Models Core off ers BSL - 2, BSL - 3 and select agent facilities for basic and translational research for small animal studies.
This model is a unique tool for the assessment of the efficacy of anti-hTNF agents in the blockade of the transmembrane form of human TNF.
This model offers unique capabilities for preclinical assessment of thrombosis risk in a patient - specific manner, including efficacy testing of anti-thrombotic agents, elucidation of mechanism of action, and, potentially, biomarker identification, all providing a much - needed platform for drug discovery and development.
Both recent experience with immunotherapy for clearance of Aβ in AD, and their own (and Prothena's) experience with AS - clearing immunotherapies in animal models, indicate that in order to be effective as disease - modifying agents when administered alone, therapies that remove proteinaceous aggregates from the brain must be initiated in the early clinical or even preclinical stages of the disease, before the burden of other forms of aging damage becomes entrenched.
The preclinical models are also used for trialling novel anti-metastatic agents targeting gene products found to drive metastasis.
Collagen Antibody Induced Arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used for the fast preclinical efficacy evaluation of candidate therapeutic agents targeting pathogenic mechanisms and inflammatory processes of arthritis.
«This in vitro model should give us the ability to assess a lot more compounds and agents at a reduced cost, with reduced animal use, and we should be able to do it faster,» said Bushdid, who is director of the Drug Development division's Toxicology & Pathology Services and discipline leader for the Developmental & Reproductive Toxicology (DART) program.
The profiling methods used in this research to identify molecular changes may be a general approach for differentiating the molecular pathology of disease models resulting from agent - specific effects, such as the effects of the two neurotoxins used in this research.
That's when concerns emerged about whether the chicken embryo model was the best platform for assessing teratogens, or agents that cause malformations in an embryo.
As a medical anthropologist, she specializes in the study of multidisciplinary models for integrative medicine (healing circles) and the emergence of health coaches as novel agents in health behavior change.
As a medical anthropologist, she specializes in the study of multi-disciplinary models for integrative medicine (healing circles) and the emergence of Health Coaches as novel agents in health behavior change.
As a medical anthropologist, she specializes in the study of collaborative models for integrative medicine and the emergence of health coaches as novel agents in health behavior change.
For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasFor example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasfor example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.
BeautifulPeople members benefit from having model bookers, talent scouts, production companies, and agents who utilize the site looking for talent.
I was a photographer and model agent for many years.
But PPL sites won't do it, because then they may have no one left: They created a model where they pay agents, who get them girls, for mails and chats.
Dating Advice From Justin Kim of «America's Next Top Model»: «If Someone Is Already on Your Team, You Shouldn't Be Looking for Free Agents.»
I have looking for someone that wants to have fun but know how to treat me I love the finer things in life:) Right now i work as a modeling agent.
beautifulpeople members benefit from having model bookers, talent scouts, production companies, and agents who utilize the site looking for talent.
But to do so she'll have to navigate a town of predators, who include, in no particular order: the modeling agent who tells her to lie about her age (Christina Hendricks); the hot photographer who immediately calls for a closed set and asks her to get naked (Desmond Harrington); the other supermodels who, Jesse points out, undergo plastic surgery «to look like a second - rate version of me» (Bella Heathcote, Abbey Lee); the mountain lion who somehow ends up in her grimy motel room in the San Fernando Valley (casting information unknown); the helpful makeup artist who moonlights down at the morgue (Jena Malone); and the motel manager who might be a murderer and is definitely a pimp (Keanu Reeves).
When Steven Soderbergh cast Andie MacDowell in his debut feature, he was well aware that she wasn't highly regarded; writing in his journal at the time, he described the reaction from his casting agent as «Uh-oh, Steven fell for the model.»
The show also helped launch / further the careers of cast members Penny Johnson, Jeremy Piven, Janeane Garofalo, Sarah Silverman and Mary Lynn Rajskub, and in later seasons brought in Bob Odenkirk as Larry's new agent (modeled on the real - life Ari Emanuel, also the model for Piven's character on Entourage) and «Kid in the Hall» Scott Thompson as the gay assistant to homophobic Hank, and the writing staff included Peter Tolan (co-creator of Rescue Me) and Judd Apatow.
Some of his most noted modeling work was with top agents Click, Next, Ford NY, and Arlene Wilson, to name a few, and he also appeared in print ad campaigns for the likes of Guess, Dolce Gabana, American Eagle Outfitters, Mossimo, and Esprit, as well as many others.