In the study, the genetic targets were messenger RNA (mRNA) that code for certain proteins known to be biomarkers for
aggressive breast cancer cells.
Not exact matches
Inflammatory
breast cancer is a rare and
aggressive form of
breast cancer that occurs when malignant
cells block the skin and lymph vessels of the...
She carried in her
cells a dangerous genetic mutation and died when she was 28, after refusing surgery for her
aggressive, inherited
breast cancer.
«We discovered that the
aggressive cancer cells that are spreading in colon,
breast, and skin
cancer contained a much higher portion of the protein PITPNC1, than the non-
aggressive cancer cells,» says researcher Nils Halberg of the CELLNET Group at the Department of Biomedicine at UiB.
Cardiff University scientists have developed a novel anti-cancer stem
cell agent capable of targeting
aggressive tumour forming
cells common to
breast, pancreas, colon and prostate
cancers.
A COMPOUND that slows the proliferation of triple - negative
breast cancer cells in lab tests could lead to the first drugs to target this
aggressive type of tumour.
Extensive studies have found that 20 % to 30 % of
breast cancers are characterized by over-expression of HER2, which makes the
cancer cells grow and divide faster, leading to a
cancer that's more
aggressive and more likely to be resistant to the standard of care.
«Our data clearly suggests that AKR1B1 overexpression represents an oncogenic event that is responsible for the
aggressive behaviors of basal - like
breast cancer cells,» Dong explains.
«By understanding how stress accelerates invasion in
aggressive breast tumor
cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some
aggressive breast cancers.»
The study, which will be published December 21 in the Journal of
Cell Biology, suggests that the loss of these particular Numb proteins makes
breast cancers more
aggressive and resistant to chemotherapy, but points the way toward new therapeutic approaches that could improve patient outcome by preserving p53 levels.
«The research showed that the
aggressive form of basal
breast cancer cells may be dependent on PLK4 for survival and that depleting it induced
cell death,» says Dr. Mak.
The discovery of this stem
cell could explain why some
breast cancers recur despite
aggressive chemotherapy.
«What began with the question «what makes a particular
aggressive form of
breast cancer cells keep growing?»
Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of
cells from melanoma, the most
aggressive type of skin
cancer, as well as
breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.
A new study shows coibamide A has potent anti-
cancer activity in mice and
cell cultures that model brain tumors and triple negative
breast cancer, two of the most
aggressive and difficult - to - treat types of
cancer.
For years, scientists have observed that tumor
cells from certain
breast cancer patients with
aggressive forms of the disease contained low levels of mitochondrial DNA.
Now, University of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content leads human
breast cancer cells to take on
aggressive, metastatic properties.
The team's findings, published online in Nature
Cell Biology, explored HIF - 1's role in triple - negative
breast cancer (TNBC), an
aggressive and hard - to - treat form of the disease.
The growth rate of the
cells exploded, and they quickly became disorganized masses characteristic of early stage,
aggressive breast cancer, the team reports in the 7 February issue of the Journal of Experimental Medicine.
Mutations in the gene increase rat susceptibility to mammary
cancer and FRY reduced the growth of highly
aggressive human
breast cancer cells.
«Inflammatory
breast cancer is a rare and very
aggressive disease in which
cancer cells block lymph vessels in the skin of the
breast.
The signatures of the
breast stem
cells in the fetus were stunningly similar to the stem - like
cells found in
aggressive breast cancers, including a significant fraction of a virulent
cancer subtype known as «triple - negative.»
A New Twist in
Breast Cancer Working with mice, scientists have shown that a protein made by a gene called TWIST may be the proverbial red flag that can accurately distinguish cells that drive aggressive, metastatic breast cancer from other breast cancer
Breast Cancer Working with mice, scientists have shown that a protein made by a gene called TWIST may be the proverbial red flag that can accurately distinguish cells that drive aggressive, metastatic breast cancer from other breast cancer
Cancer Working with mice, scientists have shown that a protein made by a gene called TWIST may be the proverbial red flag that can accurately distinguish
cells that drive
aggressive, metastatic
breast cancer from other breast cancer
breast cancer from other breast cancer
cancer from other
breast cancer
breast cancer cancer cells.
Low levels of a tiny RNA fragment in
cells are associated with metastatic
breast cancer in humans and increases the
aggressive spread of
breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.
Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative
breast cancer — so called because tumor
cells in this particularly
aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).
Inflammatory
breast cancer (IBC) is an
aggressive form of the disease that occurs when
cancer cells enter the skin and lymph vessels of the
breasts.
The
breast cancer cells inhibited by the combination were of a notoriously
aggressive type known as triple - negative.