Sentences with phrase «aggressive cancer subtypes»

Not exact matches

This study shows that the mesenchymal subtype is the most aggressive subtype, that it has the poorest prognosis among affected patients, and that cancer stem cells isolated from the mesenchymal subtype have significantly higher levels of the enzyme ALDH1A3 compared with the proneural subtype.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

A team of researchers led by UC San Francisco scientists has identified a new drug target for triple - negative breast cancer, an aggressive disease subtype that has the poorest outcomes and accounts for as many as one in five cases.

The study showed that one of the three subtypes of prostate cancer the researchers identified, which they called PCS1, was generally aggressive.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the Cancer Center, lead author of the study.

When researchers looked at subtypes of pancreatic cancer, they found the lowest levels of PDX1 were actually in the most aggressive cancers.

In the era of personalized cancer therapy, patients with TNBC remain at considerably higher risk of relapse and death than patients with other breast cancer subtypes, due to the aggressive nature of TNBC and the lack of newer targeted therapies for the disease.

The signatures of the breast stem cells in the fetus were stunningly similar to the stem - like cells found in aggressive breast cancers, including a significant fraction of a virulent cancer subtype known as «triple - negative.»

The researchers found that non-Hispanic white women were more likely to have smaller tumors, and more likely to have the less - aggressive HR + / HER2 - subtype of breast cancer, compared with African - American women, who were more likely to have large tumors, more likely to have the aggressive triple - negative breast cancer, and 40 to 70 percent more likely to be diagnosed at stage 4 of all subtypes of breast cancer.

The researchers found that minority women are more likely to have aggressive subtypes of breast cancer and were less likely to receive guidelines - based standard of care as compared to non-Hispanic white women.

High - grade serous ovarian cancer (HGSOC) is an aggressive subtype that causes nearly 90 % of ovarian cancer deaths.

A network of transcription factors may drive different subtypes of aggressive bladder cancer, allowing researchers to turn one type of tumor into another

Together, these data indicate that MELK is a normally non-essential kinase, but is critical for BBC and thus represents a promising selective therapeutic target for the most aggressive subtype of breast cancer.

Despite marked advances in breast cancer therapy, basal - like breast cancer (BBC), an aggressive subtype of breast cancer usually lacking estrogen and progesterone receptors, remains difficult to treat.