Sentences with phrase «aggressive form of the disease»

We don't really understand why they are there but they appear to be associated with more aggressive forms of the disease.

For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA.

Now, nearly a quarter century later, there's something that helps some people with the most aggressive form of the disease.

Fortunately, many people with bladder cancer have a less aggressive form of the disease (lower grade, superficial bladder cancer) that is usually not life threatening.

The problem is identifying which men may develop more aggressive forms of the disease.

This provides a potential target for treating triple negative breast cancer, the most aggressive form of the disease.

Researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center are reporting a potentially important discovery in the battle against one of the most devastating forms of leukemia that accounts for as many as one in five children with a particularly aggressive form of the disease relapsing within a decade.

«We've shown a causal role for this mitochondrial defect and identified a candidate biomarker for aggressive forms of the disease.

The cells and differentiated neurons (of a type damaged by the disease) were derived from patients that carried alpha - synuclein mutations and develop aggressive forms of the disease.

«Gene sequencing study reveals unusual mutations in endometriosis: Findings advance search for new ways to classify aggressive forms of the disease.»

While treatment may be warranted for a younger man with rapidly growing prostate cancer, its benefits are less clear for, say, a man in his 80s with a less aggressive form of the disease who is more likely to die from other causes before the cancer would become apparent.

Women with the variant were at much higher risk for cancer, had more recurrences, were often hit with multiple cancers and were more likely to die from aggressive forms of these diseases.

But in 2008, a study showed considerable evidence that another species of bacterium, M. lepromatosis, causes a distinct and aggressive form of the disease called «diffuse lepromatous leprosy,» found in Mexico and the Caribbean.

Doctors are already using drugs, such as Herceptin, that specifically target malfunctioning genetic pathways in tumors, but no such therapies are currently available for certain aggressive forms of the disease, such as the triple negative subtype.

Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so called because tumor cells in this particularly aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).

Men with BRCA1 / 2 mutations who develop prostate cancer tend to develop these cancers at an earlier age than average and may develop more aggressive forms of the disease.

They say the study, published in Molecular Cancer Research, provides key insights into the most aggressive form of the disease, which is one of the deadliest human cancers.

The work, published in the journal Oncogene, breaks new ground in understanding why some cancers progress and spread faster than others and may offer clinicians a biomarker that would distinguish patients with particularly aggressive forms of disease, helping personalize treatment approaches.

Men with a higher BMI and waist circumference had an increased risk of high grade prostate cancer, an aggressive form of the disease (10 % increased risk for BMI for every 5 kg / m2 increase and 13 % for waist circumference for every 10 cm increase).

Diagnosing the aggressive form of the disease is an important unmet need.

Researchers have identified a gene that, when mutated, appears to cause the juvenile form of glaucoma, an aggressive form of the disease that can strike teenagers.

The prostate - specific antigen (PSA) test was once the recommended screening tool for detecting prostate cancer, but there is now disagreement over the use of this test because it can't predict which men with elevated PSA levels will actually develop an aggressive form of the disease.

What we show is that the non-aggressive and aggressive forms of the disease are, in fact, created by related but distinctly different genetic abnormalities,» says Marileila Garcia, PhD, investigator at the University of Colorado Cancer Center and professor at the CU School of Medicine.

Although therapies against specific signaling proteins or pathways have been remarkably successful at treating certain cancers, the tumors frequently develop resistance, leading to even more aggressive forms of the disease.

Grima used two mouse models of Huntington's disease: one with a human version of the mutant Huntingtin protein and another with an aggressive form of the disease that contains only the first portion of the mouse Huntingtin protein.

When the investigators analyzed the genes of MECs infected with EBV, they found genetic characteristics associated with high - grade, estrogen - receptor - negative breast cancer (an aggressive form of the disease).

Additionally, a form of indolent B cell lymphoma, which progresses slowly with only mild symptoms, can transform without warning into an aggressive form of the disease.

They found that when an MS - like disease was induced in mice genetically engineered to be deficient in Tob1, the mice had significantly earlier onset compared with wild - type mice, and developed a more aggressive form of the disease.

However, JHD is a more aggressive form of the disease, and the brain of young people might be more sensitive to side - effects, so it might be harder to treat even if the drug works well.

The Salk scientists now hope to develop a mouse model of small cell lung cancer, a more aggressive form of the disease that's been linked to smoking.

Carriers of germline mutations in BRCA2 have at least five times greater risk of prostate cancer and frequently develop a more aggressive form of the disease.

Low Cholesterol May Shrink Risk for High - Grade Prostate Cancer Men with lower cholesterol are less likely than those with higher levels to develop high - grade prostate cancer, an aggressive form of the disease with a poorer prognosis, according to results of a Johns Hopkins collaborative study.

Triple - negative breast cancer (TNBC) is an aggressive form of the disease accounting for 12 to 18 percent of breast cancers.

BUFFALO, N.Y. — Although men with prostate cancer usually respond to standard treatment with hormone therapy or chemotherapy, many will eventually experience progression or recurrence despite treatment — particularly those with high - risk or aggressive forms of the disease.

Inflammatory breast cancer is a rare and aggressive form of the disease that accounts for about 1 % to 5 % of all breast cancers.

Inflammatory breast cancer (IBC) is an aggressive form of the disease that occurs when cancer cells enter the skin and lymph vessels of the breasts.

This can be a sign of inflammatory breast cancer, a rare and aggressive form of the disease.

One reason may be that men in the study seemed to develop Alzheimer's at a younger age than women and had a more aggressive form of the disease.