Sentences with phrase «aggressive luminal»
Patients with basal breast cancer generally have a poorer prognosis than those with the less aggressive luminal - type breast cancer.
https://www.sciencedaily.com/ Not exact matches
«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.
The luminal cells generally lead to more aggressive tumors.
The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.
The researcher highlights that «the subtype Epi - Luminal B behaves particularly aggressive form, and is associated with reduced survival of patients.
This model should be a powerful tool for testing therapies for aggressive ER + breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.