«We found a striking difference between the metabolic profiles of poorly aggressive and highly
aggressive ovarian tumor cells, particularly with respect to their production and use of the amino acid glutamine,» said lead researcher Deepak Nagrath of Rice.
Not exact matches
Importantly, elevated BRCA1 methylation was confined to patients diagnosed with so - called high - grade serous
tumors, the most
aggressive variant of
ovarian cancer, which also is the variant associated with BRCA1 mutations.
The team collected
tumors from 68 women affected with
ovarian and uterine CSs to try to determine the molecular basis of the
tumor's
aggressive behavior.
In a major breakthrough for
ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly
aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments.
«What we see over and over in trying to treat some of the most
aggressive and intractable cancers, including many lung, brain,
ovarian, breast, melanoma and sarcoma
tumors, is that the
tumor fights back.