Sentences with phrase «aggressive tumor cell»
«Mathematical modeling can identify ways to limit aggressive tumor cell growth.»
https://www.sciencedaily.com/ Not exact matches
«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»
Scientists have uncovered how tumor cells in aggressive uterine cancer can switch disguises and spread so quickly to other parts of the body.
They told her she needed aggressive chemotherapy and radiation to kill the cancer cells in her softball - sized tumor.
In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.
Metastasis, the strategy adopted by tumor cells to transform into an aggressive form of cancer, are often associated with a gloomy prognosis.
«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.
The team was surprised to observe that these very aggressive tumors arise from mature, pigment - producing cells called melanocytes.
The luminal cells generally lead to more aggressive tumors.
Conventional, high - dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors» recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.
An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).
Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.
«Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0,» Malta Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0,» Malta tumor cells closer to 0,» Malta said.
Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of muscle and other soft tissue.
In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.
«Aggressive cancers contain regions where the cancer cells are starved for oxygen and die off, yet patients with these tumors generally have the worst outcome.
«By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers.»
Because of this lack of receptors, common cancer drugs can't «find» the cells, and doctors must treat the cancer with extremely aggressive and highly toxic treatment strategies,» said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center.
Of the 297, 127 people had glioblastoma and 170 had a lower grade glioma, which is also a tumor of glial cells, but less aggressive than glioblastoma.
«We found a striking difference between the metabolic profiles of poorly aggressive and highly aggressive ovarian tumor cells, particularly with respect to their production and use of the amino acid glutamine,» said lead researcher Deepak Nagrath of Rice.
Genetically modified Salmonella bacteria target tumors and make the immune system extra aggressive toward cancer cells.
By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.
«New tumor analysis method identifies high - risk prostate cancer: Cancer cells» genetic pathways show which patients are likely to develop aggressive types of the disease.»
They found that, by using math models to understand the complex dynamics within cancers, they could use small changes in the environment to promote the growth of cells that are less aggressive and thereby decrease tumor growth.
Study leader Fausto J. Rodriguez, M.D., associate professor of pathology at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Kimmel Cancer Center, says the new study sought to sort out what makes the more aggressive NF1 - related tumors genetically different from low grade tumors and normal, healthy cells.
Genetically modified «hunter» T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, Penn Medicine researchers report in a new study this week in Science Translational Medicine.
Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.
Chimeric antigen receptor (CAR) T cell therapy, which edits a cancer patient's T cells to recognize their tumors, has successfully helped patients with aggressive blood cancers but has yet to show the ability to treat solid tumors.
This causes genomic instability in developing immune cells and, in the absence of a working tumor suppressor protein such as p53, an aggressive form of lymphoma develops in mice.
A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character — from aggressive to static, and no longer shedding cells that can colonize distant organs of the body.
A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.
For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA.
The study's findings, published in the journal Cancer Research, are the first to use these combined agents as an immune stimulator and may have the potential to kill cancerous cells in solid tumors, including some of the most aggressive cancers that form in the lung and pancreas.
Such targets have recently been discovered in cell lines derived from aggressive childhood tumors using phenotypic profiling and RNAi screening.
Hypoxia, or a lack of oxygen, is one example of a phenomenon that should weaken the tumor, but instead, the malignant cells are able to compensate and drive more aggressive disease behavior.
These cells are thought to break off from the original tumor and circulate in the blood, and may be a sign of an aggressive tumor.
Not surprisingly, the more aggressive a tumor, the more likely it is to engraft — probably because those cancer cells are particularly adept at growing and spreading.
Loskog AS, Fransson ME, and Totterman TT AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model.
However, unfortunately the mechanisms of tumor cells have the ability to resist to immunotherapy and patients who relapse with acquired resistance to BRAF and MEK inhibitors often present with melanomas that display a much more aggressive and invasive phenotype [13, 14].
University of Hawai'i Cancer Center researchers have identified an essential driver of tumor cell invasion in glioblastoma, the most aggressive form of brain cancer that can occur at any age.
«With 100 million mutations, each capable of altering a protein in some way, there is a high probability that a significant minority of tumor cells will survive, even after aggressive treatment,» said study director Chung - I Wu, PhD, professor of ecology and evolution at the University of Chicago.
In the new study, published online March 27, 2018, in Cell Reports, a team led by UCSF's David Raleigh, MD, PhD, found that increased activity of a gene known as FOXM1 appears to be responsible for the aggressive growth and frequent recurrence of these tumors.
LA JOLLA, CA — Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain...
It has been postulated that hypoxia contributes directly to the development of more aggressive cancers by exerting selective pressure on the tumor cell population to favor cells that can survive decreased O2 and nutrients [18 — 20].
The CRISPR - Cas9 genome editing system could help fight cancer, and now, researchers have used the tool to target what they call cancer's command center, in a treatment that's been shown in mice to shrink aggressive tumors and increase survival rates, without harming healthy cells.
«Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0,» Dr. Malta Tumor cells closer to 1 were more similar to stem cells and significantly more aggressive than tumor cells closer to 0,» Dr. Malta tumor cells closer to 0,» Dr. Malta said.
«We expected Ezh2 to be an oncogene in this aggressive tumor, but our gene - editing work revealed it to be a tumor suppressor,» said corresponding author Martine Roussel, Ph.D., a member of the Department of Tumor Cell Biology at St. Jude Children's Research Hosptumor, but our gene - editing work revealed it to be a tumor suppressor,» said corresponding author Martine Roussel, Ph.D., a member of the Department of Tumor Cell Biology at St. Jude Children's Research Hosptumor suppressor,» said corresponding author Martine Roussel, Ph.D., a member of the Department of Tumor Cell Biology at St. Jude Children's Research HospTumor Cell Biology at St. Jude Children's Research Hospital.
«It appears that a conspiracy among three proteins is required to drive this most aggressive form of medulloblastoma, but the precise details of interaction still need to be worked out,» said co-author Charles J. Sherr, M.D., Ph.D., chair of the St. Jude Department of Tumor Cell Biology and a Howard Hughes Medical Institute (HHMI) investigator.
«This has important implications for tumor development because certain cells might be more aggressive than others,» Beck said.
Although some tumors may be formed by initiating cells that do not resemble stem cells, it is likely that stem cell — like tumor cells are more aggressive at forming tumors, with a higher likelihood of relapse and metastasis.