Sentences with phrase «aggressive tumors»

It is a breeding ground for aggressive tumors such as in ovarian and gastrointestinal cancer.

But by the same token, if it's a particularly aggressive tumor, then it's possible they will live less than a year.

In their paper published online in the Journal of Clinical Oncology, the researchers report that several genetic characteristics of more aggressive tumors were significantly more prevalent in African American patients and appeared to be associated with a greater risk of tumor recurrence.

«Our results show that a diet oriented towards the prevention of aggressive tumors in the prostate should probably include important elements of the Mediterranean diet such as fish, legumes, and olive oil, and suggest that a high intake of fruits, vegetables, and whole grains might not be enough.»

However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of highly aggressive tumors in immunodeficient mice after transplantation under the kidney capsule.

Canine osteosarcoma (cOSA), the most common primary bone cancer in dogs, is a highly aggressive tumor with an estimated spread (or metastasis) rate of approximately 90 %.

Further, lignans in the diet are associated with less aggressive tumor characteristics in women who have been diagnosed with breast cancer.

«Hypoxia is a nearly universal hallmark of aggressive tumor growth, and up until now, we really haven't been able to home in on a pathway responsible for this behavior,» said Altieri, who is also director of The Wistar Institute Cancer Center and the Robert & Penny Fox Distinguished Professor.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.

Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread.

The team was surprised to observe that these very aggressive tumors arise from mature, pigment - producing cells called melanocytes.

«Our imaging technology has the potential to differentiate aggressive tumors from low - risk tumors.

«Mathematical modeling can identify ways to limit aggressive tumor cell growth.»

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

«Researcher discovers metabolite of prostate cancer drug more effective at treating aggressive tumors.»

Comprehensive and compassionate treatment of breast cancer patients with an interest in aggressive tumor types like IBC

Nasal tumors are locally aggressive tumors of the nasal passages.

«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

Chemotherapy and other cancer treatments are supposed to get rid of the disease, but a new study finds they can elicit aggressive tumor growth instead, STAT reports today.

In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments.

As in the knock - out mice, aggressive tumors failed to thrive and were reduced to low - grade tumors looking more like cysts; metastasis, while not completely abolished as in the knock - out mice, was reduced some 70 percent.

Pleomorphic invasive lobular carcinoma is a unique subset of lobular breast cancer that has abnormally aggressive tumor cells and results in poorer outcomes than the classic lobular breast cancer.

Loskog AS, Fransson ME, and Totterman TT AdCD40L gene therapy counteracts T regulatory cells and cures aggressive tumors in an orthotopic bladder cancer model.

These new insights may prove particularly beneficial for older patients that have aggressive meningiomas, because elderly patients have more trouble tolerating the cranial surgeries or recurrent radiation therapies that are currently used to control aggressive tumors.

These two aspects of tumor progression (hypoxia and reoxygenation) cooperate to provide growth advantages essential for the progressive development of aggressive tumors [21].

The CRISPR - Cas9 genome editing system could help fight cancer, and now, researchers have used the tool to target what they call cancer's command center, in a treatment that's been shown in mice to shrink aggressive tumors and increase survival rates, without harming healthy cells.

Here, we tested whether human gastric cancers, which are among the most aggressive tumor entities, express the cellular receptor of Shiga toxin, the glycosphingolipid globotriaosylceramide (Gb3 / CD77).

Since completing the initial paper published Thursday, the team has analyzed 50 more samples from eye fluid of retinoblastoma patients, including those with less aggressive tumors whose eyes were saved, to get a start on determining what factors might be at play in tumor progression.

About 50 percent to 70 percent of patients with aggressive tumors do not respond to standard chemotherapy and suffer recurring tumors, Berry said.

In these prior studies higher MELK expression in more aggressive tumor sample / cell lines is often correlated with other cell cycle genes.

Previous studies characterizing MELK expression in triple negative breast cancer and other aggressive tumor types somewhat diminish the novelty of this work.

Grading a tumor The grade describes how aggressive a tumor is, including how likely it is to spread.

Led by Cheryl Thompson, PhD, the study is the first - of - its - kind to show an association between insufficient sleep and biologically more aggressive tumors as well as likelihood of cancer recurrence.

«With ongoing studies of the homologous recombination pathway and its impact on cancer development, we may identify additional genes that, when mutated, allow for either improved response to specific treatments or conversely, portend more aggressive tumor biology, and this could greatly inform development of new cancer therapies,» Heeke explains.

A Gleason score of < 6 typically indicates a less aggressive tumor with generally good prognosis.

In the case of very aggressive tumors, it could allow doctors to advise quickly removing eyes to spare children from years of needless chemotherapy when eyes are unlikely to be salvageable.

Nasal carcinomas are locally aggressive tumors with a low to moderate metastatic rate.

Canine hemangiosarcoma (HSA) is a common and highly aggressive tumor of blood vessels that is oftentimes fatal.

However, those who do (nearly 30,000 each year) develop aggressive tumors that grow and spread rapidly, sometimes even after radical surgery to remove all cancerous tissue.

Aggressive tumor growth is linked to high activity of a macromolecular assembly called RNA polymerase I.

The number of mutations within each tumor and the prevalence of the basal - like and mesenchymal stem - like subtypes — all of which suggest more aggressive tumors — was also greater in the tumors of African American patients.

Some studies have found that pets who have microchips are at an increased risk of cancer, particularly of aggressive tumors that grow at the site of the chip.

BRAF mutations, which occur in about 40 to 50 percent of these patients, have been associated with aggressive tumors and decreased ability of tumors to respond to radioactive iodine, typically the first line of treatment in these patients.

In the new study, the researchers used a combination of four different therapies to activate both of the immune system's two branches, producing a coordinated attack that led to the complete disappearance of large, aggressive tumors in mice.