In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly
aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments.
Not exact matches
In 2009 he had been diagnosed with a type of rapidly growing brain
tumor called a high - grade astrocytoma that, despite
aggressive treatment, eventually evolved into a glioblastoma — the highly malignant brain
tumor that also took the lives of Vice President Joe Biden's son, Beau, in 2015 and former Sen. Ted Kennedy in 2009.
The team was surprised to observe that these very
aggressive tumors arise from mature, pigment - producing cells
called melanocytes.
Several studies have supported a role for cancer stem cells in the
aggressive brain
tumors called glioblastoma, but those studies involved inducing human
tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.
Drugs that enhance a process
called oxidative stress were found to kill rhabdomyosarcoma
tumor cells growing in the laboratory and possibly bolstered the effectiveness of chemotherapy against this
aggressive tumor of muscle and other soft tissue.
Importantly, elevated BRCA1 methylation was confined to patients diagnosed with so -
called high - grade serous
tumors, the most
aggressive variant of ovarian cancer, which also is the variant associated with BRCA1 mutations.
Aggressive tumor growth is linked to high activity of a macromolecular assembly
called RNA polymerase I.
One such example is a rare,
aggressive childhood brain
tumor called primitive neuroectodermal
tumor of the central nervous system (CNS - PNET).
The CRISPR - Cas9 genome editing system could help fight cancer, and now, researchers have used the tool to target what they
call cancer's command center, in a treatment that's been shown in mice to shrink
aggressive tumors and increase survival rates, without harming healthy cells.
Researchers led by St. Jude Children's Research Hospital scientists have worked out how a crucial cancer - related protein, a «histone writer»
called Ezh2, plays a role in suppressing as well as driving the most
aggressive form of the brain
tumor medulloblastoma.
Many women are «triple negative» No one yet knows precisely why, but African - American women are roughly twice as likely as white women to have triple - negative breast cancer — so
called because
tumor cells in this particularly
aggressive form of the disease test negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER - 2).
These
tumors are
called vaccine - associated sarcomas and are very
aggressive, rapidly growing cancerous
tumors.
When the problem is something as insidious and painful as the
aggressive, malignant
tumors that make up hemangiosarcoma, you can be left feeling helpless due to the limitations of so -
called modern medicine.