Research carried out at the Division of Genetics at Friedrich - Alexander - Universität Erlangen - Nürnberg (FAU) with support from the Institute for Human Genetics has now discovered another molecular cause for a particularly
aggressive type of leukemia in infants.
These findings provide renewed hope for developing new treatments for
this aggressive type of leukemia.»
DNMT3A is among the most frequently mutated genes in
an aggressive type of leukemia, and it plays a significant role in how this disease develops.
We hope that these new insights will allow us to increase our understanding of the molecular mechanisms that result in cancer and to more effectively treat
this aggressive type of leukemia.»
Not exact matches
However, genetic mutations in a gene called mixed lineage
leukemia, or MLL, lead to an
aggressive subtype
of B - ALL known as MLL - rearranged, which is the most common
type of acute lymphoblastic
leukemia in infants.
The new study, published March 14 in the Journal
of Clinical Investigation, focused on a particularly
aggressive form
of B - cell acute lymphoblastic
leukemia (B - ALL), the most prevalent
type of leukemia in children and young adults.
B - cell acute lymphoblastic
leukemia (B - ALL) is an
aggressive cancer that originates from a
type of white blood cell called the B lymphocyte.